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Ultrasound and Microbubble-Mediated Blood-Brain Barrier Disruption for Targeted Delivery of Therapeutics to the Brain

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Targeted Drug Delivery

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1831))

Abstract

Ultrasound and microbubble-mediated disruption of the Blood-Brain barrier is a noninvasive and targetable technique that permits the investigation of pharmacological interventions in the brain and CNS. This technique provides an alternative to direct injection of agents into the brain parenchyma or chemical disruption of the Blood-Brain barrier. Here, we detail one protocol for inducing transient Blood-Brain barrier disruption in a rodent model using a commercially available microbubble contrast agent (Definity).

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Author information

Authors and Affiliations

  1. Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada

    Meaghan A. O’Reilly & Kullervo Hynynen

  2. Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

    Meaghan A. O’Reilly & Kullervo Hynynen

  3. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada

    Kullervo Hynynen

Authors
  1. Meaghan A. O’Reilly
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  2. Kullervo Hynynen
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Corresponding author

Correspondence to Meaghan A. O’Reilly .

Editor information

Editors and Affiliations

  1. Vivian L. Smith Department of Neurosurgery, University of Texas Health Science, Center at Houston, Houston, Texas, USA

    Rachael W. Sirianni

  2. Department of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia, USA

    Bahareh Behkam

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O’Reilly, M.A., Hynynen, K. (2018). Ultrasound and Microbubble-Mediated Blood-Brain Barrier Disruption for Targeted Delivery of Therapeutics to the Brain. In: Sirianni, R., Behkam, B. (eds) Targeted Drug Delivery. Methods in Molecular Biology, vol 1831. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8661-3_9

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  • DOI: https://doi.org/10.1007/978-1-4939-8661-3_9

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8659-0

  • Online ISBN: 978-1-4939-8661-3

  • eBook Packages: Springer Protocols

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