A Platform for Comprehensive Genomic Profiling in Human Cancers and Pharmacogenomics Therapy Selection

  • Tadayuki KouEmail author
  • Masashi Kanai
  • Mayumi Kamada
  • Masahiko Nakatsui
  • Shigemi Matsumoto
  • Yasushi Okuno
  • Manabu Muto
Part of the Methods in Molecular Biology book series (MIMB, volume 1825)


Recent innovations in next-generation sequencing (NGS) technologies have enabled comprehensive genomic profiling of human cancers in the clinical setting. The ability to profile has launched a worldwide trend known as precision medicine, and the fusion of genomic profiling and pharmacogenomics is paving the way for precision medicine for cancer. The profiling is coupled with information about chemical therapies available to patients with specific genotypes. As a result, the chemogenomic space in play is not only the standard chemical and genome space but also the mutational genome and chemical space. In this chapter, we introduce clinical genomic profiling using an NGS-based multiplex gene assay (OncoPrime™) at Kyoto University Hospital.

Key words

Multiplex gene assay Next-generation sequencing Precision medicine Pharmacogenomics Clinical execution 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Tadayuki Kou
    • 1
    Email author
  • Masashi Kanai
    • 1
  • Mayumi Kamada
    • 2
  • Masahiko Nakatsui
    • 2
  • Shigemi Matsumoto
    • 1
  • Yasushi Okuno
    • 2
  • Manabu Muto
    • 1
  1. 1.Department of Therapeutic Oncology, Graduate School of MedicineKyoto UniversityKyotoJapan
  2. 2.Department of Biomedical Data Intelligence, Graduate School of MedicineKyoto UniversityKyotoJapan

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