Insights in Organometallic Synthesis of Various Adamantane Derivatives with Sigma Receptor-Binding Affinity and Antiproliferative/Anticancer Activity

  • Ioannis PapanastasiouEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1824)


Organometallic reactions, such as those involving Grignard and organocadmium reagents, are very useful but require prudent laboratory skills. In many papers related to the medicinal chemistry of adamantane derivatives with sigma receptor (σR)-binding affinity and antiproliferative/anticancer activity, organometallics play a crucial role in the synthetic pathways. In this work, the experimental procedures utilizing Grignard and organocadmium reagents are presented in detail, because these techniques are not analyzed and are important in the rational drug design.

Key words

Adamantane derivatives Sigma receptor Organocadmium reaction Grignard reaction 


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Health Sciences, Department of Pharmacy, Division of Pharmaceutical ChemistryNational and Kapodistrian University of Athens, Panepistimiopolis—ZografouAthensGreece

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