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Developing Network Models of Multiscale Host Responses Involved in Infections and Diseases

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Computational Cell Biology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1819))

Abstract

Complex interactions involved in host response to infections and diseases require advanced analytical tools to infer drivers of the response in order to develop strategies for intervention. This chapter discusses approaches to assemble interactions ranging from molecular to cellular levels and their analysis to investigate the cross talk between immune pathways. Particularly, construction of immune networks by either data-driven or literature-driven methods is explained. Next, graph theoretic approaches for probing static network properties as well as visualization of networks are discussed. Finally, development of Boolean models for simulation of network dynamics to investigate cross talk and emergent properties are considered along with Boolean-like models that may compensate for some of the limitations encountered in Boolean simulations. In conclusion, the chapter will allow readers to construct and analyze multiscale networks involved in immune responses.

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Author information

Authors and Affiliations

  1. Medical Scientist Training Program and Biophysics, Structural & Computational Biology graduate program, Rochester, NY, USA

    Rohith Palli

  2. Departments of Microbiology and Immunology, Rochester, NY, USA

    Juilee Thakar

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  1. Rohith Palli
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  2. Juilee Thakar
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Correspondence to Juilee Thakar .

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Editors and Affiliations

  1. NNF Center for Protein Research, University of Copenhagen, Copenhagen, Denmark

    Louise von Stechow

  2. Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark

    Alberto Santos Delgado

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Palli, R., Thakar, J. (2018). Developing Network Models of Multiscale Host Responses Involved in Infections and Diseases. In: von Stechow, L., Santos Delgado, A. (eds) Computational Cell Biology. Methods in Molecular Biology, vol 1819. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8618-7_18

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  • DOI: https://doi.org/10.1007/978-1-4939-8618-7_18

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8617-0

  • Online ISBN: 978-1-4939-8618-7

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