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Computational Cell Biology pp 235–247Cite as

Systems Biology Analysis to Understand Regulatory miRNA Networks in Lung Cancer

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1819))

Abstract

Lung cancer has currently the highest cancer-related mortality rate worldwide. MicroRNAs (miRNAs) are small noncoding RNAs that play a fundamental role in gene expression and are linked to disease progression of different cancer types such as lung cancer. However, functional characterization is made difficult by the fact that miRNAs generally regulate several mRNA interaction partners, resulting in complex regulatory networks. Thus, analysis of the network biology of miRNAs is essential for comprehensive understanding of their regulatory effects in lung cancer. A deeper understanding of miRNA networks in cancer could finally serve as a basis for the development of new therapeutic interventions. Here, we present a systems biology approach to analyze regulatory miRNA interaction networks to get better insight into their function.

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Acknowledgment

We thank BMBF for funding (FKZ: 031L0129B).

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    Authors and Affiliations

    1. Functional Genomics and Systems Biology Group, Department of Bioinformatics, Biocenter, Würzburg, Germany

      Meik Kunz, Andreas Pittroff & Thomas Dandekar

    2. BioComputing Unit, EMBL Heidelberg, Heidelberg, Germany

      Thomas Dandekar

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    1. Meik Kunz
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    2. Andreas Pittroff
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    3. Thomas Dandekar
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    Correspondence to Thomas Dandekar .

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    Editors and Affiliations

    1. NNF Center for Protein Research, University of Copenhagen, Copenhagen, Denmark

      Louise von Stechow

    2. Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark

      Alberto Santos Delgado

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    Kunz, M., Pittroff, A., Dandekar, T. (2018). Systems Biology Analysis to Understand Regulatory miRNA Networks in Lung Cancer. In: von Stechow, L., Santos Delgado, A. (eds) Computational Cell Biology. Methods in Molecular Biology, vol 1819. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8618-7_11

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    • DOI: https://doi.org/10.1007/978-1-4939-8618-7_11

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    • Publisher Name: Humana Press, New York, NY

    • Print ISBN: 978-1-4939-8617-0

    • Online ISBN: 978-1-4939-8618-7

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