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Characterization of the Differential Progression of Left Ventricular Remodeling in a Rat Model of Pressure Overload Induced Heart Failure. Does Clip Size Matter?

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Experimental Models of Cardiovascular Diseases

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1816))

Abstract

Despite the use of inbred animals, phenotypic variability is usually encountered in rats subjected to pressure overload. This chapter describes techniques for creating a rat model of pressure overload by ascending aortic banding procedure and noninvasive characterization of the variable phenotypes by means of echocardiography. We address the variable phenotypes encountered in this model with moderate versus severe ascending aortic banding. We also describe some of the echocardiographic and hemodynamic parameters and the degree of interstitial fibrosis and extracellular matrix remodeling encountered in each of the different phenotypes.

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Acknowledgments

This work is supported by NIH R01 HL117505, HL 119046, HL129814, 128072, HL131404, R01HL135093, a P50 HL112324, and two Transatlantic Fondation Leducq grants. We would like to acknowledge the Gene Therapy Resource Program (GTRP) of the National Heart, Lung, and Blood Institute, National Institutes of Health.

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Authors and Affiliations

  1. Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA

    Antoine H. Chaanine

  2. Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Roger J. Hajjar

Authors
  1. Antoine H. Chaanine
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  2. Roger J. Hajjar
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Corresponding author

Correspondence to Antoine H. Chaanine .

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Editors and Affiliations

  1. Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Kiyotake Ishikawa

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Chaanine, A.H., Hajjar, R.J. (2018). Characterization of the Differential Progression of Left Ventricular Remodeling in a Rat Model of Pressure Overload Induced Heart Failure. Does Clip Size Matter?. In: Ishikawa, K. (eds) Experimental Models of Cardiovascular Diseases. Methods in Molecular Biology, vol 1816. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8597-5_15

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  • DOI: https://doi.org/10.1007/978-1-4939-8597-5_15

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8596-8

  • Online ISBN: 978-1-4939-8597-5

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