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DNA-Assisted Molecular Lithography

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DNA Nanotechnology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1811))

Abstract

During the past decade, DNA origami has become a popular method to build custom two- (2D) and three-dimensional (3D) DNA nanostructures. These programmable structures could further serve as templates for accurate nanoscale patterning, and therefore they could find uses in various biotechnological applications. However, to transfer the spatial information of DNA origami to metal nanostructures has been limited to either direct nanoparticle-based patterning or chemical growth of metallic seed particles that are attached to the DNA objects. Here, we present an alternative way by combining DNA origami with conventional lithography techniques. With this DNA-assisted lithography (DALI) method, we can create plasmonic, entirely metallic nanostructures in a highly accurate and parallel manner on different substrates. We demonstrate our technique by patterning a transparent substrate with discrete bowtie-shaped nanoparticles, i.e., “nanoantennas” or “optical antennas,” with a feature size of approximately 10 nm. Owing to the versatility of DNA origami, this method can be effortlessly generalized to other shapes and sizes.

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Acknowledgments

Financial support from the Academy of Finland (projects 286845, 130900, 218182, 263526, 289947, 135193), Jane and Aatos Erkko Foundation, Sigrid Jusélius Foundation, Vilho, Yrjö and Kalle Väisälä Foundation and Finnish Cultural Foundation is gratefully acknowledged. This work was carried out under the Academy of Finland Centers of Excellence Programme (2014–2019).

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Authors and Affiliations

  1. Department of Physics, Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland

    Boxuan Shen & J. Jussi Toppari

  2. Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, Aalto, Finland

    Boxuan Shen & Veikko Linko

Authors
  1. Boxuan Shen
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  2. Veikko Linko
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  3. J. Jussi Toppari
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Corresponding author

Correspondence to J. Jussi Toppari .

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Editors and Affiliations

  1. Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

    Giampaolo Zuccheri

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Shen, B., Linko, V., Toppari, J.J. (2018). DNA-Assisted Molecular Lithography. In: Zuccheri, G. (eds) DNA Nanotechnology. Methods in Molecular Biology, vol 1811. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8582-1_20

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  • DOI: https://doi.org/10.1007/978-1-4939-8582-1_20

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8581-4

  • Online ISBN: 978-1-4939-8582-1

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