Abstract
Over the last few years, different types of magnetic particles have been investigated and successfully used in sample preparation, of which iron oxides are the most popular, due to their low price and low toxicity. For analytical purposes, these particles have always been modified and functionalized with different materials to improve their stability and introduce new surface properties. Here we describe the preparation of silica-coated iron oxide particles functionalized with C18 and their application as solid-phase extraction sorbents coupled in-line with capillary electrophoresis for determining drugs of abuse in human urine.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Baciu T, Botello I, Borrull F, Calull M, Aguilar C (2015) Capillary electrophoresis and related techniques in the determination for drugs of abuse and their metabolites. TrAC Trends Anal Chem 74:89−108
Fanali S, Aturki Z, Rocco A (2015) Forensic drugs analysis: a review of miniaturized separation techniques. LCGC Eur 28:200–209
Baciu T, Borrull F, Calull M, Aguilar C (2015) Determination of cocaine in abuser hairs by capillary electrophoresis: monitoring compliance to a detoxification program. Bioanalysis 7:437–447
Botello I, Borrull F, Calull M, Aguilar C, Somsen GW, de Jong GJ (2012) In-line solid-phase extraction-capillary electrophoresis coupled with mass spectrometry for determination of drugs of abuse in human urine. Anal Bioanal Chem 403:777–784
Tennico YH, Remcho VT (2010) In-line extraction employing functionalized magnetic particles for capillary and microchip electrophoresis. Electrophoresis 31:2548–2557
PubChem (2016) Open chemistry database. https://pubchem.ncbi.nlm.nih.gov. Accessed 30 Sep 2016
Morales-Cid G, Diez-Masa JC, de Frutos M (2013) On-line immunoaffinity capillary electrophoresis based on magnetic beads for the determination of alpha-1 acid glycoprotein isoforms profile to facilitate its use as biomarker. Anal Chim Acta 773:89−96
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media, LLC, part of Springer Nature
About this protocol
Cite this protocol
Baciu, T., Borrull, F., Aguilar, C., Calull, M. (2018). Sensitivity Enhancement in Capillary Electrophoresis Using Magnetic Particles as Solid-Phase Extraction Sorbents for the Determination of Drugs of Abuse in Urine. In: Musah, R. (eds) Analysis of Drugs of Abuse. Methods in Molecular Biology, vol 1810. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8579-1_8
Download citation
DOI: https://doi.org/10.1007/978-1-4939-8579-1_8
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-8578-4
Online ISBN: 978-1-4939-8579-1
eBook Packages: Springer Protocols