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Comprehensive Drug Screening by Thermal Desorption and Pyrolysis Combined with Direct Analysis in Real Time-Mass Spectrometry (TDP/DART-MS)

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Analysis of Drugs of Abuse

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1810))

Abstract

Rapid and accurate analysis of drugs using direct analysis in real time-mass spectrometry (DART-MS) combined with thermal desorption pyrolysis (TDP/DART-MS) is described in this chapter. Rapid drug screening is very important in cases of suspected drug abuse. However, acquiring accurate analytical data requires highly optimized sample handling and technical expertise. Although rapid drug analysis using mass spectrometry provides reliable data, it is not commonly used because of its complexity. Thus, a comprehensive analysis system for drugs that requires minimal optimization of sample preparation and analytical conditions is strongly desired. DART-MS involves ambient ionization mass spectrometric analysis with little to no sample preparation. We have coupled this approach with thermal TDP/DART-MS and demonstrate how it can be used to detect drugs in complex matrices such as urine or blood.

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Author information

Authors and Affiliations

  1. Department of Legal Medicine, Graduate School of Medicine, Chiba University, Chiba-shi, Chiba-ken, Japan

    Hiroko Abe, Daisuke Yajima & Hirotato Iwase

  2. BioChromato, Inc., Fujisawa-shi, Kanagawa-ken, Japan

    Chikako Takei

  3. AMR, Inc., Meguro-ku, Tokyo, Japan

    Motoshi Sakakura

  4. Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Hirotato Iwase

Authors
  1. Hiroko Abe
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  2. Chikako Takei
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  3. Motoshi Sakakura
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  4. Daisuke Yajima
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  5. Hirotato Iwase
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Corresponding author

Correspondence to Chikako Takei .

Editor information

Editors and Affiliations

  1. Department of Chemistry, State University of New York at Albany, Albany, New York, USA

    Rabi A. Musah

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© 2018 Springer Science+Business Media, LLC, part of Springer Nature

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Abe, H., Takei, C., Sakakura, M., Yajima, D., Iwase, H. (2018). Comprehensive Drug Screening by Thermal Desorption and Pyrolysis Combined with Direct Analysis in Real Time-Mass Spectrometry (TDP/DART-MS). In: Musah, R. (eds) Analysis of Drugs of Abuse. Methods in Molecular Biology, vol 1810. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8579-1_11

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  • DOI: https://doi.org/10.1007/978-1-4939-8579-1_11

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8578-4

  • Online ISBN: 978-1-4939-8579-1

  • eBook Packages: Springer Protocols

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