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Pre-Clinical and Clinical Methods in Brain Trauma Research pp 111–121Cite as

Development of a Rodent Model of Closed Head Injury: The Maryland Model

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Part of the book series: Neuromethods ((NM,volume 139))

Abstract

Brain injury due to closed frontal head impact is a common mechanism in civilian traumatic brain injury (TBI). Researchers have developed a variety of models of traumatic brain injury in rodents, using both open and closed methods of injury. However, these models fail to reproduce the frontal impact of force commonly found in human TBI, result in significant focal injury such as skull fractures or focal contusions, and, in certain cases, carry an unacceptably high mortality. The Maryland TBI model provides an alternative rodent model to address these shortcomings. Here, we describe the rationale for the development of the Maryland TBI model. We then provide a detailed procedural overview of the model. We then summarize relevant pathological findings in the model. Finally, we compare the model to other existing closed head injury models in rodents, both with regard to advantages and limitations of the model.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA

    Erik Hayman, Kaspar Kaledjian, Vladimir Gerzanich & J. Marc Simard

Authors
  1. Erik Hayman
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  2. Kaspar Kaledjian
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  3. Vladimir Gerzanich
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  4. J. Marc Simard
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Corresponding author

Correspondence to J. Marc Simard .

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Editors and Affiliations

  1. Department of Pediatric Surgery, McGovern Medical School, The University of Texas Health Sciences Center at Houston, Houston, Texas, USA

    Amit K. Srivastava

  2. Department of Pediatric Surgery, McGovern Medical School, The University of Texas Health Sciences Center at Houston, Houston, Texas, USA

    Charles S. Cox

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Hayman, E., Kaledjian, K., Gerzanich, V., Simard, J.M. (2018). Development of a Rodent Model of Closed Head Injury: The Maryland Model. In: Srivastava, A., Cox, C. (eds) Pre-Clinical and Clinical Methods in Brain Trauma Research. Neuromethods, vol 139. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8564-7_7

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  • DOI: https://doi.org/10.1007/978-1-4939-8564-7_7

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8563-0

  • Online ISBN: 978-1-4939-8564-7

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