HLA Typing from Short-Read Sequencing Data with OptiType
The established standards for HLA genotyping rely on targeted DNA sequencing techniques. However, the increasing abundance of short-read sequencing data has prompted a demand for computational tools capable of HLA typing from general purpose sequencing data as well. OptiType is a software that performs HLA typing from short-read DNA and RNA sequencing data, and this chapter guides the user through its installation and usage.
KeywordsHLA class I typing RNA-Seq Whole-exome Seq OptiType Mapping In silico Bioinformatics
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