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Protein Scaffolds pp 277–292Cite as

Peptide Amphiphile Micelles for Vaccine Delivery

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1798))

Abstract

Peptide subunit vaccines enable the specific activation of an immune response without the shortcomings of killed or attenuated pathogens. However, peptide subunit vaccines tend to be less immunogenic than those based on whole organisms. To improve peptide immunogenicity, biomaterials-based platforms have been developed. One such platform, the peptide amphiphile micelle platform, has displayed a unique ability to dramatically improve observed immune responses. Here we describe the design, synthesis, characterization, and application of peptide amphiphile micelles to elicit a robust immune response.

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Authors and Affiliations

  1. Institute for Molecular Engineering, University of Chicago, Chicago, IL, USA

    John C. Barrett & Matthew V. Tirrell

Authors
  1. John C. Barrett
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  2. Matthew V. Tirrell
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Corresponding author

Correspondence to Matthew V. Tirrell .

Editor information

Editors and Affiliations

  1. Department of Chemistry, Occidental College, Los Angeles, California, USA

    Andrew K. Udit

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Barrett, J.C., Tirrell, M.V. (2018). Peptide Amphiphile Micelles for Vaccine Delivery. In: Udit, A. (eds) Protein Scaffolds. Methods in Molecular Biology, vol 1798. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7893-9_21

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  • DOI: https://doi.org/10.1007/978-1-4939-7893-9_21

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7892-2

  • Online ISBN: 978-1-4939-7893-9

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