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Introduction to Epidemiological Studies

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1793))

Abstract

The basic epidemiological study designs are cross-sectional, case-control, and cohort studies. Cross-sectional studies provide a snapshot of a population by determining both exposures and outcomes at one time point. Cohort studies identify the study groups based on the exposure and, then, the researchers follow up study participants to measure outcomes. Case-control studies identify the study groups based on the outcome, and the researchers retrospectively collect the exposure of interest. The present chapter discusses the basic concepts, the advantages, and disadvantages of epidemiological study designs and their systematic biases, including selection bias, information bias, and confounding.

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References

  1. Porta M (ed) (2014) A dictionary of epidemiology. Oxford University Press, Oxford

    Google Scholar 

  2. Morton NE (1997) Genetic epidemiology. Ann Hum Genet 61:1–13

    Article  CAS  PubMed  Google Scholar 

  3. Boslaugh SE (2007) Genetic epidemiology. In: Boslaugh SE (ed) Encyclopedia of epidemiology. SAGE Publications, Thousand Oaks, pp 417–420

    Google Scholar 

  4. Khoury M, Little J, Burke W (2004) Human genome epidemiology: scope and strategies. In: Human genome epidemiology. Oxford University Press, New York, pp 3–16

    Google Scholar 

  5. Cordell HJ, Clayton DG (2005) Genetic association studies. Lancet 366:1121–1131

    Article  PubMed  Google Scholar 

  6. Grimes DA, Schulz KF (2002) Descriptive studies: what they can and cannot do. Lancet (London, England). 359:145–149

    Article  Google Scholar 

  7. Grimes DA, Schulz KF (2002) Cohort studies: marching towards outcomes. Lancet (London, England). 359:341–345

    Article  Google Scholar 

  8. Ioannidis JPA, Munafò MR, Fusar-Poli P et al (2014) Publication and other reporting biases in cognitive sciences: detection, prevalence, and prevention. Trends Cogn Sci 18:235–241

    Article  PubMed  PubMed Central  Google Scholar 

  9. Evangelou E, Ioannidis JPA (2013) Meta-analysis methods for genome-wide association studies and beyond. Nat Rev Genet 14:379–389

    Article  CAS  PubMed  Google Scholar 

  10. Grimes DA, Schulz KF (2002) Bias and causal associations in observational research. Lancet (London, England) 359:248–252

    Article  Google Scholar 

  11. Gordis L (2014) Case-control and other study designs. In: Epidemiology. Saunders, Philadelphia, pp 189–214

    Google Scholar 

  12. Schulz KF, Grimes DA (2002) Case-control studies: research in reverse. Lancet (London, England). 359:431–434

    Article  Google Scholar 

  13. Parr CL, Hjartåker A, Laake P et al (2009) Recall bias in melanoma risk factors and measurement error effects: a nested case-control study within the Norwegian women and Cancer study. Am J Epidemiol 169:257–266

    Article  PubMed  Google Scholar 

  14. Wacholder S, Silverman DT, McLaughlin JK et al (1992) Selection of controls in case-control studies. III. Design options. Am J Epidemiol 135:1042–1050

    Article  CAS  PubMed  Google Scholar 

  15. Rothman K, Greenland S, Lash T (2008) Validity in epidemiologic studies. In: Modern epidemiology. Lippincott Williams & Wilkins, Philadelphia, pp 128–148

    Google Scholar 

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Correspondence to Lazaros Belbasis .

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Belbasis, L., Bellou, V. (2018). Introduction to Epidemiological Studies. In: Evangelou, E. (eds) Genetic Epidemiology. Methods in Molecular Biology, vol 1793. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7868-7_1

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  • DOI: https://doi.org/10.1007/978-1-4939-7868-7_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7867-0

  • Online ISBN: 978-1-4939-7868-7

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