Synthesis and Evaluation of Self-Assembled Nanostructures of Peptide-π Chromophore Conjugates
Peptides provide a biomolecular scaffold for solubilizing and assembling π-conjugated molecules in aqueous media. The properties of such peptide-π chromophore conjugates can be manipulated by varying the constituent amino acid residues in the peptide backbone as well as the chromophore moieties. Such a precise handle on molecular structure leads to molecules with diverse macromolecular and material properties. We developed a versatile synthetic protocol that leads to a wide range of peptide-π chromophore conjugates in which the chromophores are covalently attached to the peptide backbone such that the chromophore is flanked by two peptide chains. This “trimer” structure lends interesting self-assembly properties to these materials which may be useful for a plethora of biological applications.
Key wordsPeptides Peptide-π conjugates Self-assembly Stimuli sensitive self-assembly 1-D nanostructure
We thank Johns Hopkins University and the Department of Energy Office of Basic Energy Sciences (DE-SC0004857, J.D.T. peptide nanomaterials synthesis) for generous support.