Synthesis and Evaluation of Self-Assembled Nanostructures of Peptide-π Chromophore Conjugates

  • Tejaswini S. Kale
  • John D. Tovar
Part of the Methods in Molecular Biology book series (MIMB, volume 1777)


Peptides provide a biomolecular scaffold for solubilizing and assembling π-conjugated molecules in aqueous media. The properties of such peptide-π chromophore conjugates can be manipulated by varying the constituent amino acid residues in the peptide backbone as well as the chromophore moieties. Such a precise handle on molecular structure leads to molecules with diverse macromolecular and material properties. We developed a versatile synthetic protocol that leads to a wide range of peptide-π chromophore conjugates in which the chromophores are covalently attached to the peptide backbone such that the chromophore is flanked by two peptide chains. This “trimer” structure lends interesting self-assembly properties to these materials which may be useful for a plethora of biological applications.

Key words

Peptides Peptide-π conjugates Self-assembly Stimuli sensitive self-assembly 1-D nanostructure 



We thank Johns Hopkins University and the Department of Energy Office of Basic Energy Sciences (DE-SC0004857, J.D.T. peptide nanomaterials synthesis) for generous support.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ChemistryJohns Hopkins UniversityBaltimoreUSA
  2. 2.Department of Materials Science and EngineeringJohns Hopkins UniversityBaltimoreUSA
  3. 3.Institute for NanoBioTechnology, Johns Hopkins UniversityBaltimoreUSA

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