Abstract
Cancer photodynamic therapy (PDT) involves the absorption of light by photosensitizers (PSs) to generate cytotoxic singlet oxygen for killing cancer cells. The success of this method is usually limited by the lack of selective accumulation of the PS at cancer cells. Bioengineered viruses with cancer cell-targeting peptides fused on their surfaces are great drug carriers that can guide the PS to cancer cells for targeted cancer treatment. Here, we use cell-targeting fd bacteriophages (phages) as an example to describe how to chemically conjugate PSs (e.g., pyropheophorbide-a (PPa)) onto a phage particle to achieve targeted PDT.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Lucky SS, Soo KC, Zhang Y (2015) Nanoparticles in photodynamic therapy. Chem Rev 115:1990–2042
Dougherty TJ (1984) Photodynamic therapy for treatment of cancer. J Opt Soc Am B 1:555–555
Marcus SL (1992) Photodynamic therapy of human cancer. Proc IEEE 80:869–889
Shirasu N, Nam SO, Kuroki M (2013) Tumor-targeted photodynamic therapy. Anticancer Res 33:2823–2831
Cao BR, Yang MY, Zhu Y, Qu XW, Mao CB (2014) Stem cells loaded with nanoparticles as a drug carrier for in vivo breast cancer therapy. Adv Mater 26:4627–4631
Roberts DJH, Cairnduff F (1995) Photodynamic therapy of primary skin-cancer–a review. Br J Plast Surg 48:360–370
Cao BR, Mao CB (2009) Identification of microtubule-binding domains on microtubule-associated proteins by major coat phage display technique. Biomacromolecules 10:555–564
Smith GP, Petrenko VA (1997) Phage display. Chem Rev 97:391–410
Murugesan M, Abbineni G, Nimmo SL, Cao BR, Mao CB (2013) Virus-based photo-responsive nanowires formed by linking site-directed mutagenesis and chemical reaction. Sci Rep 3:1820
Abbineni G, Modali S, Safiejko-Mroczka B, Petrenko VA, Mao CB (2010) Evolutionary selection of new breast cancer cell-targeting peptides and phages with the cell-targeting peptides fully displayed on the major coat and their effects on actin dynamics during cell internalization. Mol Pharm 7:1629–1642
Li X, Mao CB (2014) Using phage as a platform to select cancer cell-targeting peptides. In: Lin B, Ratna B (eds) Virus hybrids as nanomaterials. Humana Press, New York, pp 57–68
Savellano MD, Pogue BW, Hoopes PJ, Vitetta ES, Paulsen KD (2005) Multiepitope HER2 targeting enhances photoimmunotherapy of HER2-overexpressing cancer cells with pyropheophorbide-a immunoconjugates. Cancer Res 65:6371–6379
Erogbogbo F, Tien CA, Chang CW, Yong KT, Law WC, Ding H, Roy I, Swihart MT, Prasad PN (2011) Bioconjugation of luminescent silicon quantum dots for selective uptake by cancer cells. Bioconjug Chem 22:1081–1088
Gandra N, Abbineni G, Qu XW, Huai YY, Wang L, Mao CB (2013) Bacteriophage bionanowire as a carrier for both cancer-targeting peptides and photosensitizers and its use in selective cancer cell killing by photodynamic therapy. Small 9:215–221
Cao BR, Xu H, Mao CB (2014) Phage as a template to grow bone mineral nanocrystals. In: Lin B, Ratna B (eds) Virus hybrids as nanomaterials. Humana Press, New York, pp 123–135
Zhu HB, Cao BR, Zhen ZP, Laxmi AA, Li D, Liu SR, Mao CB (2011) Controlled growth and differentiation of MSCs on grooved films assembled from monodisperse biological nanofibers with genetically tunable surface chemistries. Biomaterials 32:4744–4752
Grieco SHH, Wong AYK, Dunbar WS, MacGillivray RTA, Curtis SB (2012) Optimization of fermentation parameters in phage production using response surface methodology. J Ind Microbiol Biotechnol 39:1515–1522
Unwin RR, Cabanas RA, Yanagishima T, Blower TR, Takahashi H, Salmond GPC, Edwardson JM, Fraden S, Eiser E (2015) DNA driven self-assembly of micron-sized rods using DNA-grafted bacteriophage fd virions. Phys Chem Chem Phys 17:8194–8202
Acknowledgment
We would like to thank the financial support from National Institutes of Health (EB021339, CA200504 and CA195607) and Oklahoma Center for Adult Stem Cell Research (434003).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media, LLC, part of Springer Nature
About this protocol
Cite this protocol
Cao, B., Xu, H., Yang, M., Mao, C. (2018). Virus-Based Cancer Therapeutics for Targeted Photodynamic Therapy. In: Wege, C., Lomonossoff, G. (eds) Virus-Derived Nanoparticles for Advanced Technologies. Methods in Molecular Biology, vol 1776. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7808-3_41
Download citation
DOI: https://doi.org/10.1007/978-1-4939-7808-3_41
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-7806-9
Online ISBN: 978-1-4939-7808-3
eBook Packages: Springer Protocols