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Neuroepigenetic Editing

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Book cover Epigenome Editing

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1767))

Abstract

Studies of the mammalian nervous system have revealed widespread epigenetic regulation underlying gene expression intrinsic to basic neurobiological function as well as neurological disease. Over the past decade, a critical role has emerged for the neural regulation of chromatin-modifying enzymes during both development and adulthood, and in response to external stimuli. These biochemical data are complemented by numerous next generation sequencing (NGS) studies that quantify the extent of chromatin and DNA modifications in neurons. Neuroepigenetic editing tools can be applied to distinguish between the mere presence and functional relevance of such modifications to neural transcription and animal behavior. This review discusses current advances in neuroepigenetic editing, highlighting methodological considerations pertinent to neuroscience, such as delivery methods and the spatiotemporal specificity of editing. Although neuroepigenetic editing is a nascent field, the studies presented in this review demonstrate the enormous potential of this approach for basic neurobiological research and therapeutic application.

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Authors and Affiliations

  1. The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA

    Peter J. Hamilton & Eric J. Nestler

  2. Department of Pharmacology, The University of Pennsylvania, Philadelphia, PA, USA

    Carissa J. Lim & Elizabeth A. Heller

  3. Penn Epigenetics Institute, The University of Pennsylvania, Philadelphia, PA, USA

    Elizabeth A. Heller

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  1. Peter J. Hamilton
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  2. Carissa J. Lim
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  3. Eric J. Nestler
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  4. Elizabeth A. Heller
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Correspondence to Elizabeth A. Heller .

Editor information

Editors and Affiliations

  1. Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart, Germany

    Albert Jeltsch

  2. Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Marianne G. Rots

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Hamilton, P.J., Lim, C.J., Nestler, E.J., Heller, E.A. (2018). Neuroepigenetic Editing. In: Jeltsch, A., Rots, M. (eds) Epigenome Editing. Methods in Molecular Biology, vol 1767. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7774-1_5

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  • DOI: https://doi.org/10.1007/978-1-4939-7774-1_5

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7773-4

  • Online ISBN: 978-1-4939-7774-1

  • eBook Packages: Springer Protocols

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