Abstract
Cell-based immunotherapy for cancer is emerging as an attractive alternative to conventional small-molecule or antibody-based treatment. Due to the characteristics of cell-based therapy, validation of test materials before in vivo administration is required. Here we describe general validation steps for preclinical evaluation of cell-based immunotherapy. We also describe a xenograft model of human colorectal cancer. This model can be used for applied to preclinical evaluation of various cell-based therapy regimens for colorectal cancer treatment.
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Acknowledgment
This work was supported by grants funded by the KRIBB Research Initiative Program and the Korean Government (NRF-2008-0062275).
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Kang, J.S., Yoon, Y.D., Lee, M.Y., Lee, C.W., Lee, S.J., Han, SB. (2018). Testing Cell-Based Immunotherapy for Colorectal Cancer. In: Beaulieu, JF. (eds) Colorectal Cancer. Methods in Molecular Biology, vol 1765. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7765-9_19
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DOI: https://doi.org/10.1007/978-1-4939-7765-9_19
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-7764-2
Online ISBN: 978-1-4939-7765-9
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