Automated Computational Inference of Multi-protein Assemblies from Biochemical Co-purification Data
Biology has amassed a wealth of information about the function of a multitude of protein-coding genes across species. The challenge now is to understand how all these proteins work together to form a living organism, and a crucial step for gaining this knowledge is a complete description of the molecular “wiring circuits” that underlie cellular processes. In this chapter, we describe a general computational framework for predicting multi-protein assemblies from biochemical co-fractionation data.
Key wordsProtein-protein interaction Bioinformatics Machine learning Systems biology Protein interaction prediction Protein complex prediction Python Docker Cytoscape
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