Abstract
Hydrogels are materials composed mostly of water that have found use in a wide variety of applications, including tissue engineering and regenerative medicine. Aromatic peptide amphiphiles can be designed to self-assemble in aqueous solution into one-dimensional aggregates that entangle to form hydrogels with very high water content (>99 wt. %). Here, we describe the synthesis of an aromatic peptide amphiphile designed to release hydrogen sulfide (H2S), a vital biological signaling gas with significant therapeutic potential. Peptide synthesis, purification, aliquotting, and procedures for measuring H2S release are detailed.
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Acknowledgments
This work was supported by NSF Grant DMR-1454754 and the Virginia Tech Institute for Critical Technologies and Applied Science (JFC12-256).
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Kaur, K., Qian, Y., Matson, J.B. (2018). H2S Delivery from Aromatic Peptide Amphiphile Hydrogels. In: Chawla, K. (eds) Biomaterials for Tissue Engineering. Methods in Molecular Biology, vol 1758. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7741-3_15
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DOI: https://doi.org/10.1007/978-1-4939-7741-3_15
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