Macroscopic Assessment and Cut Up of Endoscopic Resection Specimens for Early Esophageal Glandular Malignancies
Pathological assessment of tissue is the gold standard for diagnosis and staging of neoplasia and provides key prognostic information for clinical management. Proper macroscopic assessment and cut-up technique is essential to ensure that the overall assessment is correct and reproducible. Endoscopic mucosal resection is a technique used for removing early neoplastic glandular lesions of the esophagus at the level of submucosa. Here, we describe the macroscopic assessment and dissection techniques used for the routine handling of endoscopic mucosal resection specimens in the clinical laboratory.
Key wordsEsophageal adenocarcinoma Endoscopic mucosal resection Macroscopic Cut up Early stage cancer
- 1.Amin M, Edge S, Greene F, Byrd D, Brookland R, Washington M, Gershenwald J, Compton C, Hess K, Sullivan D, Jessup J, Brierley J, Gaspar L, Schilsky R, Balch C, Winchester D, Asare E, Madera M, Gress D, Meyer L (eds) (2017) AJCC cancer staging manual, 8th edn. Springer, New YorkGoogle Scholar
- 2.Edge S, Byrd D, Compton C, Fritz A, Greene F, Trotti A (eds) (2010) AJCC cancer staging manual, 7th edn. Springer, New YorkGoogle Scholar
- 3.Kumarasinghe MP, Brown IS, Charlton A, De Boer B, Eckstein R, Epari K, Gill A, Lam A, Lauwers G, Streutker C, Raftopoulos S, Bourke M, Price T (2013) Endoscopic resection of the esophagus and gastro-esophageal junction: structured reported protocol, 1st edn, Published on web by Royal College of Pathologists of Australasia. http://www.rcpa.edu.au//Library/Practising-Pathology/Structured-Pathology-Reporting-of-Cancer/Cancer-Protocols
- 4.Kumarasinghe MP, Brown IS, Raftopoulos S, Bourke MJ, Charlton A, de Boer WB, Eckstein R, Epari K, Gill AJ, Lam AK, Price T, Streutker C, Lauwers GY (2014) Standardised reporting protocol for endoscopic resection for Barrett esophagus associated neoplasia: expert consensus recommendations. Pathology 46:473–480CrossRefGoogle Scholar