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Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies

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Biomarkers for Alzheimer’s Disease Drug Development

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1750))

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Abstract

Among others, the existence of pathophysiological biomarkers such as cerebrospinal fluid (CSF) Aβ-42, t-tau, and p-tau preceding the onset of Alzheimer’s disease (AD) symptomatology have shifted the conceptualization of AD as a continuum. In addition, magnetic resonance imaging (MRI) enables the study of structural and functional cross-sectional correlates and longitudinal changes in vivo and, therefore, the combination of CSF data and imaging analyses emerges as a synergistic approach to understand the structural correlates related with specific AD-related biomarkers. In this chapter, we describe the methods used in neuroimaging that will allow researchers to combine data on CSF metabolites with imaging analyses.

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Author notes

    Authors and Affiliations

    1. Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain

      Carles Falcon, Grégory Operto, José Luis Molinuevo & Juan Domingo Gispert

    2. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain

      Carles Falcon & Juan Domingo Gispert

    3. CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain

      José Luis Molinuevo

    Authors
    1. Carles Falcon
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    2. Grégory Operto
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    3. José Luis Molinuevo
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    4. Juan Domingo Gispert
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    Corresponding author

    Correspondence to José Luis Molinuevo .

    Editor information

    Editors and Affiliations

    1. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany

      Robert Perneczky

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    Falcon, C., Operto, G., Molinuevo, J.L., Gispert, J.D. (2018). Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies. In: Perneczky, R. (eds) Biomarkers for Alzheimer’s Disease Drug Development. Methods in Molecular Biology, vol 1750. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7704-8_11

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    • DOI: https://doi.org/10.1007/978-1-4939-7704-8_11

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    • Publisher Name: Humana Press, New York, NY

    • Print ISBN: 978-1-4939-7703-1

    • Online ISBN: 978-1-4939-7704-8

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