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Brain Morphometry pp 183–202Cite as

Morphometry and Genetics

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Part of the book series: Neuromethods ((NM,volume 136))

Abstract

Several twin and family studies have shown that the influence of genes on brain volume is already evident in childhood. However, the influence of those genes on brain development and structure remains unclear. Most current research was done on candidate gene polymorphisms and their possible associations with brain structural abnormalities in psychiatric diseases such as schizophrenia, major depressive disorder, and bipolar disorder. The polymorphisms are often studied through genome-wide association studies (GWAS), and the brain imaging is often done by magnetic resonance imaging (MRI) techniques, including diffusion tensor imaging (DTI). Although there are many studies on the effects of gene polymorphisms and structural neuroimaging, a comprehensive review is lacking. Thus, the scope of this chapter is to review the structural imaging genetics studies across several neuropsychiatric disorders. This chapter will review the current literature on imaging genetics studies, provide additional considerations on the imaging genetics studies of suicidal behaviors and childhood onset disorders, and also discuss studies that have investigated rare genetic variants.

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Authors and Affiliations

  1. University of Toronto, Toronto, Canada

    Ali Bani-Fatemi, Samia Tasmim, Tayna Santos, Jose Araujo & Vincenzo De Luca

Authors
  1. Ali Bani-Fatemi
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  2. Samia Tasmim
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  3. Tayna Santos
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  4. Jose Araujo
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  5. Vincenzo De Luca
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Corresponding author

Correspondence to Vincenzo De Luca .

Editor information

Editors and Affiliations

  1. IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Rome, Italy

    Gianfranco Spalletta

  2. Division of Neuropsychiatry Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA

    Fabrizio Piras

  3. IMT School for Advanced Studies–Lucca, Lucca, Italy

    Tommaso Gili

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Bani-Fatemi, A., Tasmim, S., Santos, T., Araujo, J., De Luca, V. (2018). Morphometry and Genetics. In: Spalletta, G., Piras, F., Gili, T. (eds) Brain Morphometry. Neuromethods, vol 136. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7647-8_12

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  • DOI: https://doi.org/10.1007/978-1-4939-7647-8_12

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7645-4

  • Online ISBN: 978-1-4939-7647-8

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