Abstract
This chapter describes innovations in biomarker testing that can facilitate earlier and better treatment of patients who suffer from metabolic disorders. The use of new microfluidic devices along with miniaturized biosensors and transducers enables analysis of a single drop of a blood within the time frame of a typical visit to a doctor’s office. Steps are underway so that these approaches will incorporate both biochemical and clinical data, resulting in unique bioprofiles for each patient. This will allow earlier, personalized, and more effective therapeutic options. In addition, smartphone apps for self-monitoring will be used increasingly for the best possible patient outcomes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
http://apps.who.int/iris/bitstream/10665/204871/1/9789241565257_eng.pdf
http://www3.weforum.org/docs/WEF_Harvard_HE_GlobalEconomicBurdenNonCommunicableDiseases_2011.pdf
Piot P, Caldwell A, Lamptey P, Nyrirenda M, Mehra S, Cahill K et al (2016) Addressing the growing burden of non-communicable disease by leveraging lessons from infectious disease management. J Glob Health 6:010304. https://doi.org/10.7189/jogh.06.010304
Carolan-Olah M, Duarte-Gardea M, Lechuga J (2015) A critical review: early life nutrition and prenatal programming for adult disease. J Clin Nurs 24:3716–3729
Lopes GA, Ribeiro VL, Barbisan LF, Marchesan Rodrigues MA (2016) Fetal developmental programing: insights from human studies and experimental models. J Matern Fetal Neonatal Med 23:1–7
Lee HS (2015) Impact of maternal diet on the epigenome during in utero life and the developmental programming of diseases in childhood and adulthood. Forum Nutr 7:9492–9507
Tarry-Adkins JL, Ozanne SE (2016) Nutrition in early life and age-associated diseases. Ageing Res Rev pii:S1568–1637(16)30179–9. https://doi.org/10.1016/j.arr.2016.08.003
Dixon JB (2009) Obesity and diabetes: the impact of bariatric surgery on type-2 diabetes. World J Surg 33:2014–2021
Khavandi K, Brownrigg J, Hankir M, Sood H, Younis N, Worth J (2014) Interrupting the natural history of diabetes mellitus: lifestyle, pharmacological and surgical strategies targeting disease progression. Curr Vasc Pharmacol 12:155–167
Allison BJ, Kaandorp JJ, Kane AD, Camm EJ, Lusby C, Cross CM et al (2016) Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease. FASEB J 30:1968–1975
Camm EJ, Martin-Gronert MS, Wright NL, Hansell JA, Ozanne SE, Giussani DA (2011) Prenatal hypoxia independent of undernutrition promotes molecular markers of insulin resistance in adult offspring. FASEB J 25:420–427
MartÃnez JA, Cordero P, Campión J, Milagro FI (2012) Interplay of early-life nutritional programming on obesity, inflammation and epigenetic outcomes. Proc Nutr Soc 71:276–283
Ortiz-Espejo M, Pérez-Navero JL, Olza J, Muñoz-Villanueva MC, Aguilera CM, Gil-Campos M (2013) Changes in plasma adipokines in prepubertal children with a history of extrauterine growth restriction. Nutrition 29:1321–1325
Tan HC, Roberts J, Catov J, Krishnamurthy R, Shypailo R, Bacha F (2015) Mother’s pre-pregnancy BMI is an important determinant of adverse cardiometabolic risk in childhood. Pediatr Diabetes 16:419–426
Dutton GR, Lewis CE (2015) The look AHEAD trial: implications for lifestyle intervention in type 2 diabetes mellitus. Prog Cardiovasc Dis 58:69–75
Paquot N (2015) From evidence-based medicine to personalized medicine: the example of type 2 diabetes. Rev Med Liege 70:299–305. [Article in French]
Jones PJ (2015) Inter-individual variability in response to plant sterol and stanol consumption. J AOAC Int 98:724–728
Tudos AJ, Besselink GJ, Schasfoort RB (2001) Trends in miniaturized total analysis systems for point-of-care testing in clinical chemistry. Lab Chip 1:83–95
Schumacher S, Nestler J, Otto T, Wegener M, Ehrentreich-Förster E, Michel D et al (2012) Highly-integrated lab-on-chip system for point-of-care multiparameter analysis. Lab Chip 12:464–473
Schumacher S, Ludecke C, Ehrentreich-Förster E, Bier FF (2013) Platform technologies for molecular diagnostics near the patient's bedside. Adv Biochem Eng Biotechnol 133:75–87
Peter H, Wienke J, Bier FF (2017) Lab-on-a-chip multiplex assays. Methods Mol Biol 1546:283–294
Guest FL, Guest PC, Martins-de-Souza D (2016) The emergence of point-of-care blood-based biomarker testing for psychiatric disorders: enabling personalized medicine. Biomark Med 10:431–443
Chan CP, Sum KW, Cheung KY, Glatz JF, Sanderson JE, Hempel A et al (2003) Development of a quantitative lateral-flow assay for rapid detection of fatty acid-binding protein. J Immunol Methods 279:91–100
Celenza A, Skinner K (2011) Comparison of emergency department point-of-care international normalised ratio (INR) testing with laboratory-based testing. Emerg Med J 28:136–140
van den Besselaar AM, Péquériaux NC, Ebben M, van der Feest J, de Jong K, Ganzeboom MB et al (2012) Point-of-care monitoring of vitamin K-antagonists: validation of CoaguChek XS test strips with international standard thromboplastin. J Clin Pathol 65:1031–1035
Vegt J (2017) Development of a user-friendly app for assisting anticoagulation treatment. Methods Mol Biol 1546:303–308
Burgess-Cassler A, Barriga Angulo G, Wade SE, Castillo Torres P, Schramm W (1996) A field test for the detection of antibodies to human immunodeficiency virus types 1 and 2 in serum or plasma. Clin Diagn Lab Immunol 3:480–482
Jelinek T, Grobusch MP, Schwenke S, Steidl S, von Sonnenburg F, Nothdurft HD et al (1999) Sensitivity and specificity of dipstick tests for rapid diagnosis of malaria in nonimmune travelers. J Clin Microbiol 37:721–723
Lee JH, Seo HS, Kwon JH, Kim HT, Kwon KC, Sim SJ et al (2015) Multiplex diagnosis of viral infectious diseases (AIDS, hepatitis C, and hepatitis A) based on point of care lateral flow assay using engineered proteinticles. Biosens Bioelectron 69:213–225
Wallace JA, Blum K (1982) An evaluation of the TRI Dipstick test for the detection of drugs of abuse in urine. Subst Alcohol Actions Misuse 3:129–132
Gnoth C, Johnson S (2014) Strips of hope: accuracy of home pregnancy tests and new developments. Geburtshilfe Frauenheilkd 74:661–669
Johnson S, Cushion M, Bond S, Godbert S, Pike J (2015) Comparison of analytical sensitivity and women's interpretation of home pregnancy tests. Clin Chem Lab Med 53:391–402
Hendey GW, Schwab T, Soliz T (1997) Urine ketone dip test as a screen for ketonemia in diabetic ketoacidosis and ketosis in the emergency department. Ann Emerg Med 29:735–738
Lee WC, Smith E, Chubb B, Wolden ML (2014) Frequency of blood glucose testing among insulin-treated diabetes mellitus patients in the United Kingdom. J Med Econ 17:167–175
http://www.cobas.com/home/product/urinalysis-testing/combur-test-strip.html
Schwarz E (2017) Identification and clinical translation of biomarker signatures: statistical considerations. Methods Mol Biol 1546:103–114
Chen J, Schwarz E (2017) Opportunities and challenges of multiplex assays: a machine learning perspective. Methods Mol Biol 1546:115–122
Liu MY, Xydakis AM, Hoogeveen RC, Jones PH, Smith EO, Nelson KW et al (2005) Multiplexed analysis of biomarkers related to obesity and the metabolic syndrome in human plasma, using the Luminex-100 system. Clin Chem 51:1102–1109
Purohit S, Sharma A, She JX (2015) Luminex and other multiplex high throughput technologies for the identification of, and host response to, environmental triggers of type 1 diabetes. Biomed Res Int 2015:326918. https://doi.org/10.1155/2015/326918
Op De Beéck K, Vermeersch P, Verschueren P, Westhovens R, Mariën G, Blockmans D et al (2012) Antinuclear antibody detection by automated multiplex immunoassay in untreated patients at the time of diagnosis. Autoimmun Rev 12:137–143
Nolen BM, Lokshin AE (2013) Biomarker testing for ovarian cancer: clinical utility of multiplex assays. Mol Diagn Ther 17:139–146
Kang JH, Vanderstichele H, Trojanowski JQ, Shaw LM (2012) Simultaneous analysis of cerebrospinal fluid biomarkers using microsphere-based xMAP multiplex technology for early detection of Alzheimer’s disease. Methods 56:484–934
Schaffer C, Sarad N, DeCrumpe A, Goswami D, Herrmann S, Morales J et al (2015) Biomarkers in the diagnosis and prognosis of Alzheimer’s disease. J Lab Autom 20:589–600
Lue LF, Schmitz CT, Snyder NL, Chen K, Walker DG, Davis KJ et al (2016) Converging mediators from immune and trophic pathways to identify Parkinson disease dementia. Neurol Neuroimmunol Neuroinflamm 3:e193. https://doi.org/10.1212/NXI.0000000000000193
Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM et al (2012) Identification of a biological signature for schizophrenia in serum. Mol Psychiatry 17:494–502
Papakostas GI, Shelton RC, Kinrys G, Henry ME, Bakow BR, Lipkin SH et al (2013) Assessment of a multi-assay, serum-based biological diagnostic test for major depressive disorder: a pilot and replication study. Mol Psychiatry 18:332–333
Perkins DO, Jeffries CD, Addington J, Bearden CE, Cadenhead KS, Cannon TD et al (2014) Towards a psychosis risk blood diagnostic for persons experiencing high-risk symptoms: preliminary results from the NAPLS project. Schizophr Bull 41:419–428
Chan MK, Krebs MO, Cox D, Guest PC, Yolken RH, Rahmoune H et al (2015) Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset. Transl Psychiatry 5:e601. https://doi.org/10.1038/tp.2015.91
Stelzhammer V, Haenisch F, Chan MK, Cooper JD, Steiner J, Steeb H et al (2014) Proteomic changes in serum of first onset, antidepressant drug-naïve major depression patients. Int J Neuropsychopharmacol 17(10):1599–1608
Leary PE, Dobson GS, Reffner JA (2016) Development and applications of portable gas chromatography-mass spectrometry for emergency responders, the military, and law-enforcement organizations. Appl Spectrosc 70:888–896
Schott M, Wehrenfennig C, Gasch T, Düring RA, Vilcinskas A (2013) A portable gas chromatograph with simultaneous detection by mass spectrometry and electroantennography for the highly sensitive in situ measurement of volatiles. Anal Bioanal Chem 405:7457–7467
Rollman CM, Moini M (2016) Ultrafast capillary electrophoresis/mass spectrometry of controlled substances with optical isomer separation in about a minute. Rapid Commun Mass Spectrom 30:2070–2076
Devereaux ZJ, Reynolds CA, Foley CD, Fischer JL, DeLeeuw JL, Wager-Miller J et al (2016) Matrix-assisted ionization (MAI) on a portable mass spectrometer: analysis directly from biological and synthetic materials. Anal Chem 88(22):10831–10836
Pawell RS, Inglis DW, Barber TJ, Taylor RA (2013) Manufacturing and wetting low-cost microfluidic cell separation devices. Biomicrofluidics 7:056501. https://doi.org/10.1063/1.4821315
Yager P, Edwards T, Fu E, Helton K, Nelson K, Tam MR et al (2006) Microfluidic diagnostic technologies for global public health. Nature 442:412–418
Ermantraut E, Bickel R, Schulz T, Ullrich T Tuchscheerer J (2011) Device and method for the detection of particles. USPTO Patent US8040494. Clondiag GmbH
Shafiee H, Kanakasabapathy MK, Juillard F, Keser M, Sadasivam M, Yuksekkaya M (2015) Printed flexible plastic microchip for viral load measurement through quantitative detection of viruses in plasma and saliva. Sci Rep 5:9919. https://doi.org/10.1038/srep09919
Kim JH, Yeo WH, Shu Z, Soelberg SD, Inoue S, Kalyanasundaram D (2012) Immunosensor towards low-cost, rapid diagnosis of tuberculosis. Lab Chip 12:1437–1440
Gao R, Cheng Z, deMello AJ, Choo J (2016) Wash-free magnetic immunoassay of the PSA cancer marker using SERS and droplet microfluidics. Lab Chip 16:1022–1029
Parra-Cabrera C, Samitier J, Homs-Corbera A (2016) Multiple biomarkers biosensor with just-in-time functionalization: application to prostate cancer detection. Biosens Bioelectron 77:1192–1200
Guest PC (2017) Multiplex biomarker approaches to enable point-of-care testing and personalized medicine. Methods Mol Biol 1546:311–315
www.statistica.com/statistics/274774/forecast-of-mobile-phone-users-worldwide/
Klasnja P, Pratt W (2012) Healthcare in the pocket: mapping the space of mobile-phone health interventions. J Biomed Inform 45:184–198
Ventola CL (2014) Mobile devices and apps for health care professionals: uses and benefits. P T 39:356–364
Krishna S, Boren SA, Balas EA (2009) Healthcare via cell phones: a systematic review. Telemed J E Health 15:231–240
Liao SC, Peng J, Mauk MG, Awasthi S, Song J, Friedman H (2016) Smart cup: a minimally-instrumented, smartphone-based point-of-care molecular diagnostic device. Sens Actuators B Chem 229:232–238
Yeo SJ, Choi K, Cuc BT, Hong NN, Bao DT, Ngoc NM et al (2016) Smartphone-based fluorescent diagnostic system for highly pathogenic H5N1 viruses. Theranostics 6:231–242
Guo T, Patnaik R, Kuhlmann K, Rai AJ, Sia SK (2015) Smartphone dongle for simultaneous measurement of hemoglobin concentration and detection of HIV antibodies. Lab Chip 15:3514–3520
Barbosa AI, Gehlot P, Sidapra K, Edwards AD, Reis NM (2015) Portable smartphone quantitation of prostate specific antigen (PSA) in a fluoropolymer microfluidic device. Biosens Bioelectron 70:5–14
Barton S, Swanton C (2011) Recent developments in treatment stratification for metastatic breast cancer. Drugs 71:2099–2113
Kanda M, Kodera Y (2015) Recent advances in the molecular diagnostics of gastric cancer. World J Gastroenterol 21:9838–9852
Sternberg IA, Vela I, Scardino PT (2016) Molecular profiles of prostate cancer: to treat or not to treat. Annu Rev Med 67:119–135
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media, LLC
About this protocol
Cite this protocol
Guest, F.L., Guest, P.C. (2018). Point-of-Care Testing and Personalized Medicine for Metabolic Disorders. In: Guest, P. (eds) Investigations of Early Nutrition Effects on Long-Term Health. Methods in Molecular Biology, vol 1735. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7614-0_6
Download citation
DOI: https://doi.org/10.1007/978-1-4939-7614-0_6
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-7613-3
Online ISBN: 978-1-4939-7614-0
eBook Packages: Springer Protocols