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Investigations of Early Nutrition Effects on Long-Term Health pp 403–420Cite as

Neuropsychiatric Sequelae of Early Nutritional Modifications: A Beginner’s Guide to Behavioral Analysis

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1735))

Abstract

Early parental nutritional interventions during prenatal development have been shown to result in neuropsychiatric sequelae in the adult offspring. In order to understand the impact of such nutritional interventions, the behavior of the animal has to be carefully analyzed. This chapter provides a step-by-step guide to conduct behavioral tests in adult mice for investigators without specific expertise or those without the equipment to carry out behavioral studies. We focus on tests tapping into the main behavioral abnormalities that correspond to mental illnesses. We describe the materials required and the detailed methods to conduct global assessment of parameters such as behavioral integrity and general well-being, psychomotor activity, social behavior, repetitive behavior, anxiety-like behavior, depression-like behavior, short-term spatial working memory, and spatial reference memory.

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Authors and Affiliations

  1. Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia

    Ann-Katrin Kraeuter & Zoltán Sarnyai

  2. Discipline of Biomedicine, College of Public Health, Medicine and Veterinary Sciences, James Cook University, Townsville, QLD, Australia

    Ann-Katrin Kraeuter & Zoltán Sarnyai

  3. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil

    Paul C. Guest

Authors
  1. Ann-Katrin Kraeuter
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  2. Paul C. Guest
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  3. Zoltán Sarnyai
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Corresponding author

Correspondence to Zoltán Sarnyai .

Editor information

Editors and Affiliations

  1. Debden, Essex, United Kingdom

    Paul C. Guest

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Kraeuter, AK., Guest, P.C., Sarnyai, Z. (2018). Neuropsychiatric Sequelae of Early Nutritional Modifications: A Beginner’s Guide to Behavioral Analysis. In: Guest, P. (eds) Investigations of Early Nutrition Effects on Long-Term Health. Methods in Molecular Biology, vol 1735. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7614-0_28

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  • DOI: https://doi.org/10.1007/978-1-4939-7614-0_28

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7613-3

  • Online ISBN: 978-1-4939-7614-0

  • eBook Packages: Springer Protocols

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