Genetic Association Studies in Host–Pathogen Interaction Analysis
- 1.7k Downloads
Studying host–pathogen interactions at a molecular level has been always technically challenging. Identifying the different biochemical and genetic pathways involved in the different stages of infection traditionally require complex molecular biology tools and often the use of costly animal models. In this chapter we illustrate a complementary approach to address host–pathogen interactions, taking advantage of the natural interindividual genetic diversity. The application of genetic association studies allows us to identify alleles involved in infection progression or resistance. Thus, this strategy may be useful to unravel new molecular pathways underlying host–pathogen interactions. Here we present the general steps that might be followed to plan, execute, and analyze a population-based study in order to identify genetic variants affecting human exposition to pathogens.
Key wordsHost–pathogen genetics Association study Case–control study Study design
- 2.Kimman T (2001) Genetics of infectious disease susceptibility. Springer, BerlinGoogle Scholar
- 3.Dean M, Carrington M, Winkler C et al (1996) Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Haemophilia growth and development study, multicenter AIDS cohort study, multicenter Haemophilia cohort study, San Francisco City Cohort, ALIVE study. Science 273:1856–1862CrossRefPubMedGoogle Scholar
- 5.Fisher A (1918) The correlation between relatives on the supposition of Mendelian inheritance. Trans R Soc Edinburgh 53:399–433Google Scholar
- 12.Solé X, Guinó E, Valls J, Iniesta R, Moreno V (2006) SNPStats: a web tool for the analysis of association studies. Bioinformatics Aug 1;22(15):1928–1929Google Scholar