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Comparative Analysis of Neurotoxic Potential of Synthesized, Native, and Physiological Nanoparticles

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Use of Nanoparticles in Neuroscience

Part of the book series: Neuromethods ((NM,volume 135))

Abstract

The importance of assessing the neurotoxic potential of nanoparticles is underscored by two main factors. From one side, nanoparticles are a perspective matter for use in neurotheranostics, neurosurgery, cancer treatment, and others branches of nanomedicine. From the other side, they are a component of air pollution that is considered to be a potential trigger factor for development of neuropathologies. The novelty of nanoparticle-related research is determined by unexpected physical and chemical properties of nanomaterials that often differ from those in bulk forms. Herein, we performed a comparative analysis of the neuromodulatory effects of synthesized detonation nanodiamonds, carbon dots, nanoparticles from native volcanic ash, and physiological ferritin-based nanoparticles using similar methodological approaches.

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Acknowledgments

We would like to thank our colleagues Prof. Alexander Demchenko and Maria Dekaliuk for carbon dots synthesis; Dr. Olga Leshchenko from the Bakul Institute for Superhard Materials NAS of Ukraine for the preparation of nanodiamonds and its technical characterization; Dr. Klaus Slenzka from Jacobs University in Bremen for providing JSC-1a and JSC. This work was supported by Science and Technology Center in Ukraine (#6055); the grants in the frame of Programs of NAS of Ukraine” Molecular and cellular biotechnologies for medicine, industry, and agriculture”; Scientific Space Research; HORIZON 2020, ERA-PLANET. We would like to thank Dr. Sandor Vari for support; Cedars Sinai Medical Center’s International Research and Innovation Management Program, the Association for Regional Cooperation in the Fields of Health, Science and Technology (RECOOP HST Association) for their support of our organization as participating Cedars—Sinai Medical Center—RECOOP Research Centers (CRRC).

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Authors and Affiliations

  1. Department of Neurochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine

    Arsenii Borysov, Natalia Pozdnyakova, Artem Pastukhov & Tatiana Borisova

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  1. Arsenii Borysov
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  2. Natalia Pozdnyakova
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  3. Artem Pastukhov
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  4. Tatiana Borisova
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Corresponding author

Correspondence to Tatiana Borisova .

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Editors and Affiliations

  1. Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA

    Fidel Santamaria

  2. Air Force Research Laboratory, 711 HPW/RHDR, Fort Sam Houston, Texas, USA

    Xomalin G. Peralta

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Borysov, A., Pozdnyakova, N., Pastukhov, A., Borisova, T. (2018). Comparative Analysis of Neurotoxic Potential of Synthesized, Native, and Physiological Nanoparticles. In: Santamaria, F., Peralta, X. (eds) Use of Nanoparticles in Neuroscience. Neuromethods, vol 135. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7584-6_13

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  • DOI: https://doi.org/10.1007/978-1-4939-7584-6_13

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