Functional Diffusion Magnetic Resonance Imaging

  • Rita Maria Rocha Oliveira
  • Irene Guadilla
  • Pilar López-LarrubiaEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1718)


Functional diffusion magnetic resonance imaging (fDMRI) is a noninvasive technique that allows elucidating physiological and anatomical changes at a microscopic scale by detection of water molecular displacements in tissue structures. These displacements likely reflect microstructural changes associated with neuronal or glial cells activation. In this chapter, we will describe the physical and biological concepts of fDMRI and how images of brain activation can be acquired in a preclinical setup.

Key words

Magnetic resonance imaging Functional imaging Diffusion imaging Diffusion biexponential parameters 



This work was supported by grant SAF2014-53739-R. RMRO held a contract form the Programme Erasmus + and IG held a predoctoral contract from Ministerio de Economía, Indrustria y Competitividad (MINECO) of Spain.


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Copyright information

© Springer Science+Business Media, LLC 2018

Authors and Affiliations

  • Rita Maria Rocha Oliveira
    • 1
  • Irene Guadilla
    • 1
  • Pilar López-Larrubia
    • 1
    Email author
  1. 1.Instituto de Investigaciones Biomédicas “Alberto Sols”CSIC/UAMMadridSpain

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