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Diffusion Tensor Imaging (DTI)

  • Silvia Lope-Piedrafita
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1718)

Abstract

Diffusion Tensor Imaging is an MRI technique that allows in vivo noninvasive measurement of the translational motion of water, providing information about its anisotropy (or lack of it) in different tissues. DTI has been commonly used to quantitatively measure the integrity of tissues which may be compromised by neurological disease, such as white matter tracks of the brain, which normally impart significant anisotropy to water motion in healthy brains. However, this anisotropic effect is diminished when axonal or neuronal damage is present. This chapter describes a standard protocol for DTI data acquisition in preclinical studies.

Key words

Diffusion tensor imaging Fractional anisotropy Apparent diffusion coefficient Axial diffusivity Radial diffusivity White matter Fiber tracking 

Notes

Acknowledgements

The author expresses its gratitude to Dr. Gary V. Martinez (Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA), who assisted in the proofreading of the chapter. Time allocated in the joint nuclear magnetic resonance facility of the Universitat Autònoma de Barcelona and Centro de Investigación Biomédica en Red-Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (Cerdanyola del Vallès, Spain) is gratefully acknowledged.

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Copyright information

© Springer Science+Business Media, LLC 2018

Authors and Affiliations

  1. 1.Servei de Ressonància Magnètica NuclearUniversitat Autònoma de BarcelonaCerdanyola del VallèsSpain
  2. 2.Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)Universitat Autònoma de BarcelonaCerdanyola del VallèsSpain

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