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Preclinical Arterial Spin Labeling Measurement of Cerebral Blood Flow

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Preclinical MRI

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1718))

Abstract

Magnetic resonance imaging has been utilized as a quantitative and noninvasive method to image blood flow. Arterial spin labeling (ASL) is an MRI technique that images blood flow using arterial blood water as an endogenous tracer. Herein we describe the use of ASL to measure cerebral blood flow completely noninvasively in rodents, including methods, analysis, and important considerations when utilizing this technique.

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Authors and Affiliations

  1. Department of Ophthalmology, Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

    Eric R. Muir

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  1. Eric R. Muir
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Correspondence to Eric R. Muir .

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Editors and Affiliations

  1. BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain

    María Luisa García Martín

  2. Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC/UAM, Madrid, Spain

    Pilar López Larrubia

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Muir, E.R. (2018). Preclinical Arterial Spin Labeling Measurement of Cerebral Blood Flow. In: García Martín, M., López Larrubia, P. (eds) Preclinical MRI. Methods in Molecular Biology, vol 1718. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7531-0_4

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  • DOI: https://doi.org/10.1007/978-1-4939-7531-0_4

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7530-3

  • Online ISBN: 978-1-4939-7531-0

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