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Preclinical MRI pp 315–327Cite as

Molecular Magnetic Resonance Imaging (mMRI)

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1718))

Abstract

Molecular magnetic resonance imaging (mMRI) enables the detection of a protein of interest in vivo, in a noninvasive manner. The general concept of mMRI is to target a contrast agent to a protein of interest, and to perform a contrast-sensitive MRI sequence. Typically, contrast agents are made of a “contrastophore” (the part of the construct responsible for the contrast on the images) and a targeting moiety (“pharmacophore”). Recently, the development of a new family of contrastophore carrying a high payload of iron oxide (micro-sized particles of iron oxide, MPIO) has led to a dramatic increase in the sensitivity of mMRI. Here, we describe the production of targeted MPIO using commercially available reagents and the MRI protocols to allow their detection in vivo.

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Authors and Affiliations

  1. Normandie Univ, UNICAEN, INSERM, INSERM UMR-S U1237, PhIND, Physiopathology and Imaging of Neurological Disorders, Cyceron, Caen, 14000, France

    Maxime Gauberti, Antoine P. Fournier, Denis Vivien & Sara Martinez de Lizarrondo

  2. Department of Diagnostic Imaging and Interventional Radiology, CHU Caen, Caen, France

    Maxime Gauberti

  3. Clinical Research Department, CHU Caen, Caen, France

    Denis Vivien

Authors
  1. Maxime Gauberti
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  2. Antoine P. Fournier
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  3. Denis Vivien
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  4. Sara Martinez de Lizarrondo
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Corresponding author

Correspondence to Maxime Gauberti .

Editor information

Editors and Affiliations

  1. BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain

    María Luisa García Martín

  2. Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC/UAM, Madrid, Spain

    Pilar López Larrubia

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Gauberti, M., P. Fournier, A., Vivien, D., Martinez de Lizarrondo, S. (2018). Molecular Magnetic Resonance Imaging (mMRI). In: García Martín, M., López Larrubia, P. (eds) Preclinical MRI. Methods in Molecular Biology, vol 1718. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7531-0_19

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  • DOI: https://doi.org/10.1007/978-1-4939-7531-0_19

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7530-3

  • Online ISBN: 978-1-4939-7531-0

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