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Cardiac MRI in Small Animals

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Preclinical MRI

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1718))

Abstract

Cardiac magnetic resonance (MR) imaging of mice is a valuable tool for the precise in vivo diagnosis and prognosis of heart defects. This detailed protocol describes the method of cardiac MR imaging in mice step by step. A series of MR images captures the contractile function of the mouse heart and post-processing of the image data yields morphometric parameters (myocardial mass, myocardial wall thickness, ventricular end-systolic and end-diastolic volume) as well as functional parameters (stroke volume and ejection fraction). This protocol may also serve as a starting point for MR imaging of rats, by using larger image dimensions (field-of-view) and MR hardware suitable for larger animals.

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Acknowledgement

The authors wish to thank Thomas Basse-Lüsebrink from Bruker Biospin MRI GmbH, Ettlingen, Germany, for providing the Ig-UTE image data.

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Authors and Affiliations

  1. Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany

    Min-Chi Ku, Till Huelnhagen, Thoralf Niendorf & Andreas Pohlmann

  2. DZHK (German Centre for Cardiovascular Research), Berlin, Germany

    Thoralf Niendorf

Authors
  1. Min-Chi Ku
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  2. Till Huelnhagen
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  3. Thoralf Niendorf
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  4. Andreas Pohlmann
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Corresponding author

Correspondence to Andreas Pohlmann .

Editor information

Editors and Affiliations

  1. BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain

    María Luisa García Martín

  2. Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC/UAM, Madrid, Spain

    Pilar López Larrubia

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Ku, MC., Huelnhagen, T., Niendorf, T., Pohlmann, A. (2018). Cardiac MRI in Small Animals. In: García Martín, M., López Larrubia, P. (eds) Preclinical MRI. Methods in Molecular Biology, vol 1718. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7531-0_16

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  • DOI: https://doi.org/10.1007/978-1-4939-7531-0_16

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7530-3

  • Online ISBN: 978-1-4939-7531-0

  • eBook Packages: Springer Protocols

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