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In Vivo Heteronuclear Magnetic Resonance Spectroscopy

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Preclinical MRI

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1718))

Abstract

Magnetic Resonance Spectroscopy is a technique that has the capability of measuring metabolites in vivo and, in appropriate conditions, to infer its metabolic rates. The success of MRS depends a lot on its sensitivity, which limits the usage of X-nuclei MRS. However, technological developments and refinements in methods have made in vivo heteronuclear MRS possible in humans and in small animals. This chapter provides detailed descriptions of the main procedures needed to perform successful in vivo heteronuclear MRS experiments, with a particular focus on experimental setup in 13C MRS experiments in rodents.

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Author information

Authors and Affiliations

  1. Laboratory for Functional and Metabolic Imaging (LIFMET), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

    Blanca Lizarbe, Antoine Cherix & Rolf Gruetter

  2. Department of Radiology, University of Geneva, Geneva, Switzerland

    Rolf Gruetter

  3. Department of Radiology, University of Lausanne, Lausanne, Switzerland

    Rolf Gruetter

Authors
  1. Blanca Lizarbe
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  2. Antoine Cherix
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  3. Rolf Gruetter
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Corresponding author

Correspondence to Blanca Lizarbe .

Editor information

Editors and Affiliations

  1. BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain

    María Luisa García Martín

  2. Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC/UAM, Madrid, Spain

    Pilar López Larrubia

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Lizarbe, B., Cherix, A., Gruetter, R. (2018). In Vivo Heteronuclear Magnetic Resonance Spectroscopy. In: García Martín, M., López Larrubia, P. (eds) Preclinical MRI. Methods in Molecular Biology, vol 1718. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7531-0_11

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  • DOI: https://doi.org/10.1007/978-1-4939-7531-0_11

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7530-3

  • Online ISBN: 978-1-4939-7531-0

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