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Traumatic and Ischemic Injury pp 61–81Cite as

Assessment of Cardiovascular Function and Microvascular Permeability in a Conscious Rat Model of Alcohol Intoxication Combined with Hemorrhagic Shock and Resuscitation

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1717))

Abstract

Hypotension, cardiac depression, and elevated microvascular permeability are known problems that complicate resuscitation of patients following traumatic injury, particularly those who are also intoxicated from alcohol consumption. A conscious rat model of combined alcohol intoxication and hemorrhagic shock has been used to study the hemodynamic mechanisms involved. Here, we describe using this model to study microvascular leakage and cardiac electrical activity.

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Author information

Authors and Affiliations

  1. Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA

    Travis M. Doggett, Natascha G. Alves, Sarah Y. Yuan, Srinivas M. Tipparaju & Jerome W. Breslin

  2. Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA

    Jared J. Tur & Srinivas M. Tipparaju

Authors
  1. Travis M. Doggett
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  2. Jared J. Tur
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  3. Natascha G. Alves
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  4. Sarah Y. Yuan
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  5. Srinivas M. Tipparaju
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  6. Jerome W. Breslin
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Corresponding author

Correspondence to Jerome W. Breslin .

Editor information

Editors and Affiliations

  1. Department of Surgery, Texas A&M University Health Science Center, College of Medicine, Baylor Scott and White Research Institute, Temple, Texas, USA

    Binu Tharakan

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Doggett, T.M., Tur, J.J., Alves, N.G., Yuan, S.Y., Tipparaju, S.M., Breslin, J.W. (2018). Assessment of Cardiovascular Function and Microvascular Permeability in a Conscious Rat Model of Alcohol Intoxication Combined with Hemorrhagic Shock and Resuscitation. In: Tharakan, B. (eds) Traumatic and Ischemic Injury. Methods in Molecular Biology, vol 1717. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7526-6_6

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  • DOI: https://doi.org/10.1007/978-1-4939-7526-6_6

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7524-2

  • Online ISBN: 978-1-4939-7526-6

  • eBook Packages: Springer Protocols

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