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MicroRNA and Cancer pp 75–81Cite as

Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like Gene Expression, RNA Editing, and MicroRNAs Regulation

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1699))

Abstract

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) protein family is encoded by eleven genes located in human genome. APOBECs are a family of evolutionarily conserved cytidine deaminases in vertebrates, and particularly in mammals. APOBECs play key roles in innate immunity against viral infection and retrotransposons. Subtypes of APOBEC3 can cause specific mutations in RNA and DNA at distinct preferred nucleotide contexts in human cancer. The pervasive APOBEC3s activation in the host genome converts cytosine to uracile on single-stranded DNA, which has been suggested to depend on ATR/chk1 pathways. In this chapter, we review the expression profiling of APOBEC expression in normal and disease states, discuss how microRNAs interact with APOBEC gene family, and post-transcriptionally regulate APOBEC gene expression in the APOBECA-B fusion allele and APOBEC-mediated RNA editing. It is reasonable to speculate targeting specific microRNAs may reduce host genome mutagenesis via inactivation of APOBEC deaminases.

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Acknowledgment

This work is supported by joint funding of natural science foundation of Henan province (grant #: 162300410279) and Henan science and technology research program (international collaborative project, 152102410088).

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Authors and Affiliations

  1. Translational Medical Center, Zhengzhou Central Hospital, Affiliated to Zhengzhou University, 195 Tongbai Road, Zhengzhou, 450007, People’s Republic of China

    Wei Cao M.D., Ph.D.

  2. Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California in San Francisco, 600 16th Street Mission Bay/Genentech Hall, Room N212, San Francisco, CA, 94143, USA

    Wei Wu

Authors
  1. Wei Cao M.D., Ph.D.
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  2. Wei Wu
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Correspondence to Wei Cao M.D., Ph.D. .

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Editors and Affiliations

  1. Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California in San Francisco, San Francisco, California, USA

    Wei Wu

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Cao, W., Wu, W. (2018). Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like Gene Expression, RNA Editing, and MicroRNAs Regulation. In: Wu, W. (eds) MicroRNA and Cancer. Methods in Molecular Biology, vol 1699. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7435-1_5

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  • DOI: https://doi.org/10.1007/978-1-4939-7435-1_5

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7433-7

  • Online ISBN: 978-1-4939-7435-1

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