Abstract
The role of chemicals in used daily lives is simultaneously obvious and unrevealed. These chemicals are used either in combined form or as some reagents. Around 100,000 different chemical substances find their way into routine products. At 2013, worldwide chemicals industry production was valued at 3.578 trillion dollars. Although no-one would disagree that some chemicals carry significant benefits to humanity—through their use in healthcare, for example—unfortunately some chemicals have harmful impacts on human health and the ecological system and we still don’t know enough about their long-term effects. The majority are used without proper tests being carried out on effects of its toxic on health and the environment. Hazardous chemicals are found in the tissue of nearly every individual on Earth and exposure to them has been related to several diseases and the increasing incidence of some of these conditions, and continued exposure to a blend of these chemicals, is alarming. In order to ensure that we are safe, we need chemicals to be properly tested, regulated, and more safety information. This chapter provides a general overview of the biodegradability, standard, and test method and focuses on standards and guidelines for toxicological testing. Some test methods are given. Several methods for evaluating the toxicity and biodegradability of hazardous chemical pollutants have been reviewed in this work. Moreover, it must be noted that biodegradation alone if mostly not enough for acceptance in biological disposal but that also requirements with regard to dissolution and environmental safety are formulated.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Brauer RL (2016) Safety and health for engineers. John Wiley & Sons
Bidwell P. Toxic chemicals in our environment and the role of biotransformation
Wexler P, Judson R, de Marcellus S, De Knecht J, Leinala E (2016) Health effects of toxicants: online knowledge support. Life Sci 145:284–293
Judson R, Kavlock R, Martin M, Reif D, Houck K, Knudsen T, Huang R (2013) Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. ALTEX 30(1):51
Thapar A, Zalawadia A, Pokharkar OV, Satam SS (2016) Classification of pesticides and its damaging effects: a review. Biolife 4(1):13–24
Davis S (2009) Chemical economics handbook marketing research report: benzene. SRI Consulting
Zhang W, Jiang F, Ou J (2011) Global pesticide consumption and pollution: with China as a focus. Proc Int Acad Ecol Environ Sci 1(2):125
FDA (U.S. Food and Drug Administration). Available at: http://www.fda.gov/AboutFDA/CentersOffices/OfficeofGlobalRegulatoryOperationsandPolicy/GlobalProductPathway/ucm259754.htm. Accessed 30 Feb 2017
Euromonitor International. Available at: http://www.portal.euromonitor.com/Portal/Pages/Statistics/Statistics.aspx. Accessed 30 Oct 2016)
Golberg A, Sack M, Teissie J, Pataro G, Pliquett U, Saulis G, Frey W (2016) Energy-efficient biomass processing with pulsed electric fields for bioeconomy and sustainable development. Biotechnol Biofuels 9(1):94
European Commision (2006) Environment fact sheet: reach a chemicals policy for the EU http://www.ec.euroupa.eu/environment/chemicals/reach/fact_sheet.pdf
Gauthier AM, Fung M, Panko J, Kingsbury T, Perez AL, Hitchcock K, Abelmann A (2015) Chemical assessment state of the science: evaluation of 32 decision-support tools used to screen and prioritize chemicals. Integr Environ Assess Manag 11(2):242–255
Mahadevan B, Snyder RD, Waters MD, Benz RD, Kemper RA, Tice RR, Richard AM (2011) Genetic toxicology in the 21st century: reflections and future directions. Environ Mol Mutagen 52(5):339–354
Eide-Haugmo I, Brakstad OG, Hoff KA, da Silva EF, Svendsen HF (2012) Marine biodegradability and ecotoxicity of solvents for CO2-capture of natural gas. Int J Greenhouse Gas Control 9:184–192
Luo Z, Xia C, Fan H, Chen X, Peng B (2011) The biodegradabilities of different oil-based fatliquors. J Am Oil Chem Soc 88(7):1029–1036
Boichenko S, Vovk O, Iakovlieva A, Kumeiko S (2015) Comparative analysis of standard testing methods for measuring fuels & lubricants biodegradation
Government of Canada (2006) Invest in Canada: chemical sector http://www.investincanada.comen921Industry.html. Accessed 3 Apr 2017
Privy Council Office (2006) A framework for the application of precaution in science-based decision making about risk. www.pcobcp.gc.ca/default.asp?Language=E&Page=publications&Sub=precaution&doc=precaution_e.htlm. Accessed 3 Apr 2017
Government of Canada (2005) Guidelines for the notification and testing of new substances: chemicals and polymers, pursuant to section 69 of the CanadianEnvironmental Protection Act, 1999, Version 2005. SBN0-662-69285-3 Cat. no.: En84-25/2005 EPS M-688.Ottawa, Canada
Government of Canada (2005) New substances notification regulations (chemicals and polymers) http://canadagazette.gc.ca/partII/2005/20050921/html/sor247-e.html. Accessed 3 Apr 2017
Crist E (2013) On the poverty of our nomenclature. Environ Humanit 3(1):129–147
van Leeuwen CJ, Vermeire TG (2007) Risk assessment of chemicals: an introduction. Springer Science & Business Media, Dordrecht
Johnson AC, Sumpter JP (2016) Are we going about chemical risk assessment for the aquatic environment the wrong way? Environ Toxicol Chem 35(7):1609–1616
Paustenbach DJ (2015) Human and ecological risk assessment: theory and practice (Wiley classics library). John Wiley & Sons
Manuele FA (2013) On the practice of safety. John Wiley & Sons
Li WC (2014) Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil. Environ Pollut 187:193–201
Hussen A (2012) Principles of environmental economics and sustainability: an integrated economic and ecological approach. Routledge
Aven T (2016) Risk assessment and risk management: review of recent advances on their foundation. Eur J Oper Res 253(1):1–13
Schmid G, Schömann K (2004) Managing social risks through transitional labour markets. Towards a European social model. SISWO, Amsterdam
Kasperson JX, Kasperson RE (2013) Global environmental risk. Routledge
Haimes YY (2015) Risk modeling, assessment, and management. John Wiley & Sons
Glendon AI, Clarke S, McKenna E (2016) Human safety and risk management. Crc Press
Chemicals DOFO (2005) OECD guideline for testing of chemicals
Toräng L (2003) Biodegradation rates of chemicals in surface water and groundwater assessed in batch simulation tests. Ph. D. Thesis (Doctoral dissertation, Technical University of DenmarkDanmarksTekniskeUniversitet, Department of Environmental EngineeringInstitut for VandogMiljøteknologi)
Gruiz K, Molnár M, Nagy ZM, Hajdu C (2015) Fate and behavior of chemical substances in the environment. In: Engineering tools for environmental risk management: 2. Environmental toxicology. CRC Press, pp 71–124
Kowalczyk A, Martin TJ, Price OR, Snape JR, van Egmond RA, Finnegan CJ, Bending GD (2015) Refinement of biodegradation tests methodologies and the proposed utility of new microbial ecology techniques. Ecotoxicol Environ Saf 111:9–22
Bradbury SP, Feitel TC, Van Leeuwen CJ (2004) Meeting the scientific needs of ecological risk assessment in a regulatory context. Environmental Science & Technology
Péry ARR, Schüürmann G, Ciffroy P, Faust M, Backhaus T, Aicher L, Andres S (2013) Perspectives for integrating human and environmental risk assessment and synergies with socio-economic analysis. Sci Total Environ 456:307–316
Patlewicz G (2005) Chemical categories and read across. European Commission Joint Research Center
Rorije E, Aldenberg T, Buist H, Kroese D, Schüürmann G (2013) The OSIRIS weight of evidence approach: ITS for skin sensitisation. Regul Toxicol Pharmacol 67(2):146–156
Vermeire T, van de Bovenkamp M, de Bruin YB, Delmaar C, van Engelen J, Escher S, Meijster T (2010) Exposure-based waiving under REACH. Regul Toxicol Pharmacol 58(3):408–420
Balls M, Combes RD, Bhogal N (2012) The use of integrated and intelligent testing strategies in the prediction of toxic hazard and in risk assessment. Adv Exp Med Biol 745:221–253
Stanton K, Kruszewski FH (2016) Quantifying the benefits of using read-across and in silico techniques to fulfill hazard data requirements for chemical categories. Regul Toxicol Pharmacol 81:250–259
Worth AP, Bassan A, De Bruijn J, Gallegos Saliner A, Netzeva T, Pavan M, Eisenreich S (2007) The role of the European chemicals bureau in promoting the regulatory use of (Q) SAR methods. SAR QSAR Environ Res 18(1–2):111–125
OECD (2004) Manual for investigation of HPV chemicals. OECD secretariat, April 2004. Online Available at: http://www.oecd.org/
Mishra S, Autiero M, Balteau M, Tencalla F, Petry T (2016) Reducing uncertainty in read across based chemical safety assessments. Toxicol Lett 258:S314
Sharifi S, Behzadi S, Laurent S, Forrest ML, Stroeve P, Mahmoudi M (2012) Toxicity of nanomaterials. Chem Soc Rev 41(6):2323–2343
Schilter B, Benigni R, Boobis A, Chiodini A, Cockburn A, Cronin MT, Worth A (2014) Establishing the level of safety concern for chemicals in food without the need for toxicity testing. Regul Toxicol Pharmacol 68(2):275–296
Teubner W, Mehling A, Schuster PX, Guth K, Worth A, Burton J, Landsiedel R (2013) Computer models versus reality: how well do in silico models currently predict the sensitization potential of a substance. Regul Toxicol Pharmacol 67(3):468–485
Eskes C, Whelan M (2016) Validation of alternative methods for toxicity testing, Advances in experimental medicine and biology (ISSN 2214-8019), vol 856. Springer International Publishing, Cham
Organization for economic co-operation and development (2006) Guidelines for the testing of chemicals. OECD, Paris
Rovida C, Alépée N, Api AM, Basketter DA, Bois FY, Caloni F, Fuchs H (2015) Integrated testing strategies (ITS) for safety assessment. ALTEX 32(1):25–40
Lilienblum W, Dekant W, Foth H, Gebel T, Hengstler JG, Kahl R, Wollin KM (2008) Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European chemicals legislation (REACH). Arch Toxicol 82(4):211–236
Basketter DA, Clewell H, Kimber I, Rossi A, Blaauboer BJ, Burrier R, Hasiwa N (2012) A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing-t4 report. ALTEX 29(1):3–91
Food US, Administration D (1995) Food additives: threshold of regulation for substances used in food-contact articles (final rule). Fed Regist 60(136):36582–36596
Dewhurst I, Renwick AG (2013) Evaluation of the threshold of toxicological concern (TTC)–challenges and approaches. Regul Toxicol Pharmacol 65(1):168–177
Barlow S (2005) Threshold of toxicological concern (TTC): a tool for assessing substances of unknown toxicity present at low levels in the diet
Munro IC, Renwick AG, Danielewska-Nikiel B (2008) The threshold of toxicological concern (TTC) in risk assessment. Toxicol Lett 180(2):151–156
Hennes EC (2012) An overview of values for the threshold of toxicological concern. Toxicol Lett 211(3):296–303
Barron MG, Lilavois CR, Martin TM (2015) MOAtox: a comprehensive mode of action and acute aquatic toxicity database for predictive model development. Aquat Toxicol 161:102–107
Verhaar HJ, Van Leeuwen CJ, Hermens JL (1992) Classifying environmental pollutants. Chemosphere 25(4):471–491
Escher BI, Hermens JL (2002) Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects. Environ Sci Technol 36(20):4201–4217
Zhao YH, Zhang XJ, Wen Y, Sun FT, Guo Z, Qin WC, Abraham MH (2010) Toxicity of organic chemicals to Tetrahymenapyriformis: effect of polarity and ionization on toxicity. Chemosphere 79(1):72–77
Worth AP, Balls M (2002) Alternative (non-animal) methods for chemicals testing: current status and future prospects. FRAME, pp 71–82
Foth H, Hayes AW (2008) Concept of REACH and impact on evaluation of chemicals. Hum Exp Toxicol 27(1):5–21
Chapman KL, Holzgrefe H, Black LE, Brown M, Chellman G, Copeman C, Kinter LB (2013) Pharmaceutical toxicology: designing studies to reduce animal use, while maximizing human translation. Regul Toxicol Pharmacol 66(1):88–103
Adeleye Y, Andersen M, Clewell R, Davies M, Dent M, Edwards S, Scott S (2015) Implementing toxicity testing in the 21st century (TT21C): making safety decisions using toxicity pathways, and progress in a prototype risk assessment. Toxicology 332:102–111
Suter GW II (2016) Ecological risk assessment. CRC press
Graham JD (2015) Legislative approaches to achieving more protection against risk at less cost. In: University of Chicago Legal Forum (Vol. 1997, No. 1, p. 3)
Duffus JH, Nordberg M, Templeton DM (2007) Glossary of terms used in toxicology, (IUPAC recommendations 2007). Pure Appl Chem 79(7):1153–1344
Singh DK (2012) Pesticide chemistry and toxicology. Bentham Science Publishers
Raies AB, Bajic VB (2016) In silico toxicology: computational methods for the prediction of chemical toxicity. Wiley Interdiscip Rev: Comput Mol Sci 6(2):147–172
Kroes R, Feron VJ (1984) General toxicity testing: sense and non-sense, science and policy. Fundam Appl Toxicol 4(3):S298–S308
Kroes R, Feron VJ (1990) Toxicity testing: strategies and conduct. Prog Predict Toxicol:15–39
Ramirez T, Daneshian M, Kamp H, Bois FY, Clench MR, Coen M, Guillou C (2013) Metabolomics in toxicology and preclinical research. ALTEX 30(2):209
Krewski D, Acosta D Jr, Andersen M, Anderson H, Bailar JC III, Boekelheide K, Kelsey KT (2010) Toxicity testing in the 21st century: a vision and a strategy. J Toxicol Environ Health, Part B 13(2–4):51–138
National Research Council (2007) Toxicity testing in the 21st century: a vision and a strategy. National Academies Press
Zhang C, Ball J, Panzica-Kelly J, Augustine-Rauch K (2016) In vitro developmental toxicology screens: a report on the progress of the methodology and future applications. Chem Res Toxicol 29(4):534–544
Abou-Donia MB (2015) Toxicology in the 21st century. Mamm Toxicol:641–650
Bhattacharya S, Zhang Q, Carmichael PL, Boekelheide K, Andersen ME (2011) Toxicity testing in the 21 st century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways. PLoS One 6(6):e20887
Weeks JA, Guiney PD, Nikiforov AI (2012) Assessment of the environmental fate and ecotoxicity of N, N-diethyl-m-toluamide (DEET). Integr Environ Assess Manag 8(1):120–134
Handy RD, Cornelis G, Fernandes T, Tsyusko O, Decho A, Sabo-Attwood T, Horne N (2012) Ecotoxicity test methods for engineered nanomaterials: practical experiences and recommendations from the bench. Environ Toxicol Chem 31(1):15–31
Buschmann J (2013) The OECD guidelines for the testing of chemicals and pesticides. Methods Mol Biol 947:37–56
Valavanidis A,Vlachogianni T (2015) Ecotoxicity test methods and ecological risk assessment ecosystems. 10:13
Tardiff RG, Rodricks JV (2013) Toxic substances and human risk: principles of data interpretation. Springer Science & Business Media
Kokkali V, van Delft W (2014) Overview of commercially available bioassays for assessing chemical toxicity in aqueous samples. TrAC Trends Anal Chem 61:133–155
Barile FA (2013) Principles of toxicology testing. CRC Press
Richardson M (2002) Environmental xenobiotics. CRC Press
Kalčíková G, Zupančič M, Levei EA, Miclean M, Englande AJ, Gotvajn AŽ (2015) Application of multiple toxicity tests in monitoring of landfill leachate treatment efficiency. Environ Monit Assess 187(8):489
Noon M, Blyton P, Morrell K (2013) The realities of work: experiencing work and employment in contemporary society. Palgrave Macmillan
Fujimoto WY (2016) 2015 Yutaka Seino distinguished leadership award lecture: the Japanese American community diabetes study and the ‘canary in the coal mine’. J Diabetes Invest 7(5):664–673
Richter E (2016) Ecotoxicological evaluation of treated wastewater and sewage sludge for sustainable use in land management. Frankfurt, Hessen
Wieczerzak M, Namieśnik J, Kudłak B (2016) Bioassays as one of the green chemistry tools for assessing environmental quality: a review. Environ Int 94:341–361
Amiard-Triquet C, Amiard JC, Mouneyrac C (2015) Predictive ecotoxicology and environmental assessment. Aquatic ecotoxicology: advancing tools for dealing with emerging risks, 463
Bitton G, Koopman B (1992) Bacterial and enzymatic bioassays for toxicity testing in the environment. In: Reviews of environmental contamination and toxicology. Springer, New York, pp 1–22
Kratasyuk VA, Esimbekova EN (2015) Applications of luminous bacteria enzymes in toxicology. Comb Chem High Throughput Screen 18(10):952–959
Tobajas M, Verdugo V, Polo AM, Rodriguez JJ, Mohedano AF (2016) Assessment of toxicity and biodegradability on activated sludge of priority and emerging pollutants. Environ Technol 37(6):713–721
Halmi MIE (2016) Rapid ecotoxicological tests using bioassay systems-a review. J Biochem Microbiol Biotechnol 4(1):29–37
Matyja K, Małachowska-Jutsz A, Mazur AK, Grabas K (2016) Assessment of toxicity using dehydrogenases activity and mathematical modeling. Ecotoxicology 25(5):924–939
MacDonald JS, Robertson RT (2009) Toxicity testing in the 21st century: a view from the pharmaceutical industry. Toxicol Sci 110(1):40–46
McKim J, James M (2010) Building a tiered approach to in vitro predictive toxicity screening: a focus on assays with in vivo relevance. Comb Chem High Throughput Screen 13(2):188–206
Zhu H, Zhang J, Kim MT, Boison A, Sedykh A, Moran K (2014) Big data in chemical toxicity research: the use of high-throughput screening assays to identify potential toxicants. Chem Res Toxicol 27(10):1643–1651
Horner S, Robinson S, Lees D, Callander R, Roberts R (2014) Target organ profiles in toxicity studies supporting human dosing: an assessment of recovery and chronic dosing. Regul Toxicol Pharmacol 70(1):270–285
De Wilde B (2005) International and national norms on biodegradability and certificationprocedures. In: Bastioli C (ed) Handbook of biodegradable polymers. RapraTechnology Ltd., Shewsbury, pp 145–181. ISBN 1-85957-389-4
Mistriotis AD, Briassoulis D, Mortier N, De Wilde B(2014) Review of standard testing methods and specifications for measuring biodegradation of bio-based materials in fresh water. Proceedings International Conference of Agricultural Engineering, Zurich
Gathergood N, Garcia MT, Scammells PJ (2004) Biodegradable ionic liquids: part I. Concept, preliminary targets and evaluation. Green Chem 6(3):166–175
Stolte S, Steudte S, Igartua A, Stepnowski P (2011) The biodegradation of ionic liquids-the view from a chemical structure perspective. Curr Org Chem 15(12):1946–1973
OECD (2006) Test guideline 425. Acute oral toxicity—up and down procedure (UDP. In: OECD guidelines for the testing of chemicals. Organisation for Economic Cooperation and Development, Paris
Docherty KM, Aiello SW, Buehler BK, Jones SE, Szymczyna BR, Walker KA (2015) Ionic liquid biodegradability depends on specific wastewater microbial consortia. Chemosphere 136:160–166
Organisation for Economic Co-operation and Development (1971) Pollution by detergents: determination of the biodegradability of anionic synthetic surface active agents. Paris: Organisation for Economic Co-operation and Development
Organisation for Economic Co-operation and Development (1976) Proposed method for the determination of the biodegradability of surfactants used in synthetic detergents. Organisation for Economic Co-operation and Development, Paris
OECD (1981) Guidelines for testing of chemicals. OECD, Paris
Struijs J, Van den Berg R (1995) Standardized biodegradability tests: extrapolation to aerobic environments. Water Res 29(1):255–262
EEC (1984) 84/449/EEC directive, annex part C: methods for the determination of ecotoxicity
Karel V (2001) Handbook of environmental data on organic-chemicals. Wiley, Hoboken
Thouand G, Durand MJ, Maul A, Gancet C, Blok H (2011) New concepts in the evaluation of biodegradation/persistence of chemical substances using a microbial inoculum. Front Microbiol 2:164
Martin TJ (2014) The influence of microbial inocula on biodegradation outcome towards enhanced regulatory assessments. University of Newcastle upon Tyne, Newcastle upon Tyne
Calza P, Vione D (2015) Surface water photochemistry. Royal Society of Chemistry
Guideline PBT (2001) OECD guideline for the testing of chemicals. The Hershberger 601
Ahtiainen J, Aalto M, Pessala P (2003) Biodegradation of chemicals in a standardized test and in environmental conditions. Chemosphere 51(6):529–537
Bhogal N, Grindon C, Combes R, Balls M (2005) Toxicity testing: creating a revolution based on new technologies. Trends Biotechnol 23(6):299–307
Zoller U (2004) Sustainable relationships: raw materials-surfactant/detergent production/formulation-usage/consumption-environment. In: Handbook of detergents, part B: environmental impact. CRC Press, pp 1–10
Karsa DR, Porter MR (2012) Biodegradability of surfactants. Springer Science & Business Media
OECD (1981) Test guideline 453. Combined chronic toxicity/carcinogenicity studies. In: OECD guidelines for the testing of chemicals. Organisation for Economic Cooperation and Development, Paris
Bowmer T, Leopold A, Schaefer E, Hanstveit R (2004) Strategies for selecting biodegradation simulation tests and their interpretation in persistence evaluation and risk assessment. Simulation Testing of Environmental Persistence (STEP):4–5
Mezzanotte V, Bertani R, DegliInnocenti F, Tosin M (2005) Influence of inocula on the results of biodegradation tests. Polym Degrad Stab 87(1):51–56
Parece TE (2015) In: Younos T (ed) Advances in watershed science and assessment, vol 33. Springer
SCHER SHENIHR SCCS (2013) Addressing the new challenges for risk assessment. Available at: http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_131.pdf http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_131.pdf. Accessed 3 Apr 2017
Van Emon JM (2015) The omics revolution in agricultural research. J Agric Food Chem 64(1):36–44
Wolff MS (2012) Breast cancer and the environment. Lancet Oncol 13(9):868
Watson B, Smith L (2009) The detox strategy: vibrant health in 5 easy steps. Simon and Schuster
Benigni R, Battistelli CL, Bossa C, Tcheremenskaia O, Crettaz P (2013) New perspectives in toxicological information management, and the role of ISSTOX databases in assessing chemical mutagenicity and carcinogenicity. Mutagenesis 28(4):401–409
High Production Volume Information System (HPVIS) (2014) US EPA. Accessed 13 Mar 2017
Reuschenbach P, Pagga U, Strotmann U (2003) A critical comparison of respirometric biodegradation tests based on OECD 301 and related test methods. Water Res 37(7):1571–1582
Pagga U (1997) Testing biodegradability with standardized methods. Chemosphere 35(12):2953–2972
Lapertot ME, Pulgarin C (2006) Biodegradability assessment of several priority hazardous substances: choice, application and relevance regarding toxicity and bacterial activity. Chemosphere 65(4):682–690
Comber M, Holt M (2010) Developing a set of reference chemicals for use in biodegradability tests for assessing the persistency of chemicals. MCC report no. MCC/007
ECHA (2017) Guidance on information requirements and chemical safety assessment. Chapter R.7b: endpoint specific guidance
Ready Biodegradability (1992) OECD Guideline for testing of chemicals
OECD 302 A (1981) OECD guidelines. OECD guidelines for testing of chemicals. Inherent Biodegradability: Modified SCAS Test. Accessed 2 Apr 2017
OECD 302 B (1992) OECD guidelines. OECD guidelines for testing of chemicals. Zahn-Wellens/EMPATest. Accessed 2 Apr 2017
OECD 302 C (1981) OECD guidelines. OECD guidelines for testing of chemicals. Inherent Biodegradability Modified MITI Test (II) Accessed 2 Apr 2017
De Wilde B, Mortier N, OWS SV, Briassoulis D, Babou M, Mistriotis A, Hiskakis M (2013) Report on current relevant biodegradation and ecotoxicity standards
Jordan A, Gathergood N (2015) Biodegradation of ionic liquids–a critical review. Chem Soc Rev 44(22):8200–8237
Kelland MA (2014) Production chemicals for the oil and gas industry. CRC Press
Tosin M, Weber M, Siotto M, Lott C, Degli-Innocenti F (2012) Laboratory test methods to determine the degradation of plastics in marine environmental conditions. Front Microbiol 3:225
Metcalfe K, Roberts T, Smith RJ, Harrop SR (2013) Marine conservation science and governance in North–West Europe: conservation planning and international law and policy. Mar Policy 39:289–295
United States Environmental Protection Agency (2011) Environmentally acceptable lubricants
den Besten PJ, Munawar M (2016) Ecotoxicological testing of marine and freshwater ecosystems: emerging techniques, trends and strategies. CRC Press
Sjollema SB, van Beusekom SA, van der Geest HG, Booij P, de Zwart D, Vethaak AD, Admiraal W (2014) Laboratory algal bioassays using PAM fluorometry: effects of test conditions on the determination of herbicide and field sample toxicity. Environ Toxicol Chem 33(5):1017–1022
Wendt I, Backhaus T, Blanck H, Arrhenius Å (2016) The toxicity of the three antifouling biocides DCOIT, TPBP and medetomidine to the marine pelagic copepod Acartiatonsa. Ecotoxicology 25(5):871–879
McGee, D. (2014). Overcoming the seasonal variations in fitness of the amphipod CorophiumVolutator as an environmental toxicology test species using laboratory cultured specimens
Tornambè A, Manfra L, Canepa S, Oteri F, Martuccio G, Cicero AM, Magaletti E (2016) Adaptation of the fish juvenile growth test (OECD TG 215, 2000) to the marine species Dicentrarchuslabrax. Ecotoxicology and environmental safety
Darby D (2012) Bioplastics industry report. Biocycle 53(8):40–44
Acknowledgments
The support provided by the Arabian Gulf Oil Co. (AGOCO) and Universiti Sains of Malaysia (USM) are greatly appreciated.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media LLC
About this protocol
Cite this protocol
El Mahdi, A.M., Aziz, H.A. (2018). A Review on Biodegradation and Toxicity Methods: Risk Assessment, Standards, and Analyses. In: Bidoia, E., Montagnolli, R. (eds) Toxicity and Biodegradation Testing. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7425-2_18
Download citation
DOI: https://doi.org/10.1007/978-1-4939-7425-2_18
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-7424-5
Online ISBN: 978-1-4939-7425-2
eBook Packages: Springer Protocols