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Acrolein: An Effective Biomarker for Tissue Damage Produced from Polyamines

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Book cover Polyamines

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1694))

Abstract

It is thought that the major factor responsible for cell damage is reactive oxygen species (ROS), but our recent studies have shown that acrolein (CH2=CH-CHO) produced from spermine and spermidine is more toxic than ROS. Thus, (1) the mechanism of acrolein production during brain stroke, (2) one of the mechanisms of acrolein toxicity, and (3) the role of glutathione in acrolein detoxification are described in this chapter.

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Acknowledgments

We are grateful to Dr. A.J. Michael for critical reading of the manuscript prior to submission.

Author information

Authors and Affiliations

  1. Amine Pharma Research Institute, Innovation Plaza at Chiba University, 1-8-15 Inohana, Chuo-ku, Chiba, 260-0856, Japan

    Kazuei Igarashi & Takeshi Uemura

  2. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan

    Kazuei Igarashi

  3. Faculty of Pharmacy, Chiba Institute of Science, 15-8 Shiomi-cho, Choshi, Chiba, 288-0025, Japan

    Keiko Kashiwagi

Authors
  1. Kazuei Igarashi
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  2. Takeshi Uemura
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  3. Keiko Kashiwagi
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Corresponding author

Correspondence to Kazuei Igarashi .

Editor information

Editors and Affiliations

  1. Department of Biology, Healthcare and Environment, Faculty of Pharmacy and Food Sciences, Section of Plant Physiology, University of Barcelona, Spain

    Rubén Alcázar

  2. Department of Biology, Healthcare and Environment, Faculty of Pharmacy and Food Sciences, Section of Plant Physiology, University of Barcelona, Spain

    Antonio F. Tiburcio

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Igarashi, K., Uemura, T., Kashiwagi, K. (2018). Acrolein: An Effective Biomarker for Tissue Damage Produced from Polyamines. In: Alcázar, R., Tiburcio, A. (eds) Polyamines. Methods in Molecular Biology, vol 1694. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7398-9_38

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  • DOI: https://doi.org/10.1007/978-1-4939-7398-9_38

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7397-2

  • Online ISBN: 978-1-4939-7398-9

  • eBook Packages: Springer Protocols

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