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Potassium Channels pp 321–341Cite as

Studying Kv Channels Function using Computational Methods

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1684))

Abstract

In recent years, molecular modeling techniques, combined with MD simulations, provided significant insights on voltage-gated (Kv) potassium channels intrinsic properties. Among the success stories are the highlight of molecular level details of the effects of mutations, the unraveling of several metastable intermediate states, and the influence of a particular lipid, PIP2, in the stability and the modulation of Kv channel function. These computational studies offered a detailed view that could not have been reached through experimental studies alone. With the increase of cross disciplinary studies, numerous experiments provided validation of these computational results, which endows an increase in the reliability of molecular modeling for the study of Kv channels. This chapter offers a description of the main techniques used to model Kv channels at the atomistic level.

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Acknowledgment

Results of the MD simulations were obtained thanks to generous allocation of computer time from GENCI France.

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Authors and Affiliations

  1. Structure et Réactivité des Systèmes Moléculaires Complexes, CNRS, Université de Lorraine, Nancy, France

    Audrey Deyawe, Marina A. Kasimova, Lucie Delemotte & Mounir Tarek

  2. L’institut du thorax, Inserm, CNRS, Université de Nantes, Nantes, France

    Gildas Loussouarn

  3. CNRS, Unité Mixte de Recherches 7565, Université de Lorraine, Boulevard des Aiguillettes, BP 70239, 54506, Vandoeuvre-lès-Nancy, France

    Mounir Tarek

Authors
  1. Audrey Deyawe
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  2. Marina A. Kasimova
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  3. Lucie Delemotte
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  4. Gildas Loussouarn
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  5. Mounir Tarek
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Corresponding author

Correspondence to Mounir Tarek .

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Editors and Affiliations

  1. Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon, USA

    Show-Ling Shyng

  2. Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon, USA

    Francis I. Valiyaveetil

  3. The Vollum Institute, Oregon Health and Science University, Portland, Oregon, USA

    Matt Whorton

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Deyawe, A., Kasimova, M.A., Delemotte, L., Loussouarn, G., Tarek, M. (2018). Studying Kv Channels Function using Computational Methods. In: Shyng, SL., Valiyaveetil, F., Whorton, M. (eds) Potassium Channels. Methods in Molecular Biology, vol 1684. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7362-0_24

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  • DOI: https://doi.org/10.1007/978-1-4939-7362-0_24

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  • Print ISBN: 978-1-4939-7361-3

  • Online ISBN: 978-1-4939-7362-0

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