Quantitation of Surface Coating on Nanoparticles Using Thermogravimetric Analysis

  • Alpana A. Dongargaonkar
  • Jeffrey D. ClogstonEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1682)


Nanoparticles are critical components in nanomedicine and nanotherapeutic applications. Some nanoparticles, such as metallic nanoparticles, consist of a surface coating or surface modification to aid in its dispersion and stability. This surface coating may affect the behavior of nanoparticles in a biological environment, thus it is important to measure. Thermogravimetric analysis (TGA) can be used to determine the amount of coating on the surface of the nanoparticle. TGA experiments run under inert atmosphere can also be used to determine residual metal content present in the sample. In this chapter, the TGA technique and experimental method are described.

Key words

TGA Surface coating Nanoparticles Colloidal metal nanoparticles Inorganic nanoparticles 



This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.


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Copyright information

© Springer Science+Business Media LLC 2018

Authors and Affiliations

  • Alpana A. Dongargaonkar
    • 1
  • Jeffrey D. Clogston
    • 1
    Email author
  1. 1.Cancer Research Technology Program, Nanotechnology Characterization LaboratoryLeidos Biomedical Research, Inc., Frederick National Laboratory for Cancer ResearchFrederickUSA

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