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Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles

  • Jing Liu
  • Jingwei Ma
  • Ke Tang
  • Bo HuangEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1660)

Abstract

Extracellular vesicles (EVs) are nanosized membrane vesicles, released by many cell types, which are an ideal drug-delivery system for antitumor therapy. Exosomes, microparticles (MP), and apoptotic bodies are the three main types of EVs. MPs are EVs with size ranges between 100 and 1000 nm. Tumor cell-derived EVs (T-EVs) can serve as a safe and efficient vehicle to specific deliver chemotherapeutic drugs or oncolytic adenoviruses for tumor treatment. In this section, we describe how to prepare EVs for therapeutic use.

Key words

Extracellular vesicles Tumor microparticles Drug delivery Chemotherapeutic drugs Oncolytic adenoviruses Tumor vaccines Tumor antigens Dendritic cells 

Notes

Acknowledgments

This work was supported by National Basic Research Program of China (2015CB932600), National Science Fund for Distinguished Young Scholars of China (81225021), and National Natural Science Foundation of China (81472735, 81472653, and 81530080). J. Liu and J. Ma contributed equally to this work.

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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Department of GastroenterologyZhongnan Hospital of Wuhan UniversityWuhanChina
  2. 2.The Hubei Clinical Center & Key Laboratory of Bowel DiseasesWuhanChina
  3. 3.Biochemistry and Molecular Biology, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  4. 4.Department of Immunology, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  5. 5.State Key Laboratory of Medical Molecular Biology and Department of Immunology, Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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