Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles
Extracellular vesicles (EVs) are nanosized membrane vesicles, released by many cell types, which are an ideal drug-delivery system for antitumor therapy. Exosomes, microparticles (MP), and apoptotic bodies are the three main types of EVs. MPs are EVs with size ranges between 100 and 1000 nm. Tumor cell-derived EVs (T-EVs) can serve as a safe and efficient vehicle to specific deliver chemotherapeutic drugs or oncolytic adenoviruses for tumor treatment. In this section, we describe how to prepare EVs for therapeutic use.
Key wordsExtracellular vesicles Tumor microparticles Drug delivery Chemotherapeutic drugs Oncolytic adenoviruses Tumor vaccines Tumor antigens Dendritic cells
This work was supported by National Basic Research Program of China (2015CB932600), National Science Fund for Distinguished Young Scholars of China (81225021), and National Natural Science Foundation of China (81472735, 81472653, and 81530080). J. Liu and J. Ma contributed equally to this work.
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