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Red Blood Cells: A Source of Extracellular Vesicles

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Extracellular Vesicles

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1660))

Abstract

During their lifetime, like all other cell types, red blood cells (RBCs) release both exosomes and plasma membrane derived EVs (ectosomes). RBC exosomes are formed only during the development of RBCs in bone marrow, and are released following the fusion of microvesicular bodies (MVB) with the plasma membrane. On the other hand, RBC EVs are generated during normal aging of RBCs in circulation by budding of the plasma membrane due to complement -mediated calcium influx, followed by vesicle shedding. This makes red blood cells and stored red cells a reliable source of EVs for basic and clinical research.

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Author information

Authors and Affiliations

  1. CloudHealth Genomics, Ltd, Shanghai, China

    Winston Patrick Kuo

  2. Weschester Biotech Project, Asbury Park, NJ, USA

    Winston Patrick Kuo

  3. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    John C. Tigges, Vasilis Toxavidis & Ionita Ghiran

Authors
  1. Winston Patrick Kuo
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  2. John C. Tigges
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  3. Vasilis Toxavidis
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  4. Ionita Ghiran
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Corresponding author

Correspondence to Winston Patrick Kuo .

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Editors and Affiliations

  1. CloudHealth Genomics, Ltd., Shanghai, China

    Winston Patrick Kuo

  2. Predicine, Inc., Hayward, California, USA

    Shidong Jia

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Kuo, W.P., Tigges, J.C., Toxavidis, V., Ghiran, I. (2017). Red Blood Cells: A Source of Extracellular Vesicles. In: Kuo, W., Jia, S. (eds) Extracellular Vesicles. Methods in Molecular Biology, vol 1660. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7253-1_2

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  • DOI: https://doi.org/10.1007/978-1-4939-7253-1_2

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7251-7

  • Online ISBN: 978-1-4939-7253-1

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