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Targeting the PI3K/AKT/mTOR Pathway in Bladder Cancer

  • Anuja Sathe
  • Roman NawrothEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1655)

Abstract

The PI3K/AKT/mTOR signaling pathway shows frequent molecular alterations and increased activity in cancer. Given its role in the regulation of cell growth, survival and metastasis, molecules within this pathway are promising targets for pharmacologic intervention. Metastatic bladder cancer (BLCA) continues to have few treatment options. Although various molecular alterations in PI3K/AKT/mTOR signaling have been described in BLCA, clinical trials with small molecule inhibitors have not met their endpoints. In this article, we summarize results from preclinical studies and clinical trials that examined PI3K pathway inhibitors in BLCA focusing on technical challenges that might result in contradictory findings in preclinical studies. Based on published data from our group, we also address challenges that need to be overcome to optimize PI3K inhibition in BLCA and enable its successful translation into the clinic.

Key words

Bladder cancer PI3K/AKT/mTOR 

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© Springer Science+Business Media LLC 2018

Authors and Affiliations

  1. 1.Department of Urology, Klinikum rechts der IsarTechnische Universität MünchenMunichGermany

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