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Fibrosis pp 117-122 | Cite as

Mouse Models of Corneal Scarring

  • Laure Rittié
  • Audrey E. K. Hutcheon
  • James D. Zieske
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1627)

Abstract

Corneal scarring is an obligatory consequence of stroma corneal injury and is a major cause of decreased visual quality and vision loss worldwide. There are currently no satisfactory intervention therapies for corneal fibrosis. In this chapter, we describe well-established in vivo corneal wound models to allow researchers to investigate epithelial and stromal responses to corneal injury.

Key words

Cornea Epithelial debridement Incision Keratectomy Mouse 

References

  1. 1.
    Friedlander M (2007) Fibrosis and diseases of the eye. J Clin Invest 117(3):576–586. doi: 10.1172/JCI31030 CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Dawson DG (2010) Corneal scars A2 - Dartt, Darlene A. In: Encyclopedia of the eye. Academic Press, Oxford, pp 499–514. doi: 10.1016/B978-0-12-374203-2.00073-7
  3. 3.
    Mahajan VB, Skeie JM, Assefnia AH et al (2011) Mouse eye enucleation for remote high-throughput phenotyping. J Vis Exp 57. doi: 10.3791/3184

Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  • Laure Rittié
    • 1
    • 3
  • Audrey E. K. Hutcheon
    • 2
  • James D. Zieske
    • 2
  1. 1.Department of DermatologyUniversity of MichiganAnn ArborUSA
  2. 2.Schepens Eye Research Institute/MEE and Department of OphthalmologyHarvard Medical SchoolBostonUSA
  3. 3.Dermatology Therapeutic AreaGlaxoSmithKlineCollegevilleUSA

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