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Fibrosis pp 117–122Cite as

Mouse Models of Corneal Scarring

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1627))

Abstract

Corneal scarring is an obligatory consequence of stroma corneal injury and is a major cause of decreased visual quality and vision loss worldwide. There are currently no satisfactory intervention therapies for corneal fibrosis. In this chapter, we describe well-established in vivo corneal wound models to allow researchers to investigate epithelial and stromal responses to corneal injury.

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References

  1. Friedlander M (2007) Fibrosis and diseases of the eye. J Clin Invest 117(3):576–586. doi:10.1172/JCI31030

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Dawson DG (2010) Corneal scars A2 - Dartt, Darlene A. In: Encyclopedia of the eye. Academic Press, Oxford, pp 499–514. doi:10.1016/B978-0-12-374203-2.00073-7

  3. Mahajan VB, Skeie JM, Assefnia AH et al (2011) Mouse eye enucleation for remote high-throughput phenotyping. J Vis Exp 57. doi:10.3791/3184

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Correspondence to James D. Zieske .

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Rittié, L., Hutcheon, A.E.K., Zieske, J.D. (2017). Mouse Models of Corneal Scarring. In: Rittié, L. (eds) Fibrosis. Methods in Molecular Biology, vol 1627. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7113-8_8

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  • DOI: https://doi.org/10.1007/978-1-4939-7113-8_8

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7112-1

  • Online ISBN: 978-1-4939-7113-8

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