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Peptide Vaccine Against Paracoccidioidomycosis

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Vaccines for Invasive Fungal Infections

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1625))

Abstract

The chapter reviews methods utilized for the isolation and characterization of a promising immunogen candidate, aiming at a human vaccine against paracoccidioidomycosis. Peptide P10 carries a T-CD4+ epitope and was identified as an internal sequence of the major diagnostic antigen known as gp43 glycoprotein. It successfully treated massive intratracheal infections by virulent Paracoccidioides brasiliensis in combination with chemotherapy.

An introduction about the systemic mycosis was found essential to understand the various options that were considered to design prophylactic and therapeutic vaccine protocols using peptide P10.

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Acknowledgments

The authors thank Fundação de Amparo a Pesquisa do Estado de São Paulo (Fapesp) for research grants and the National Research Council (CNPq) for career fellowships.

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Authors and Affiliations

  1. Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo, Brazil

    Carlos P. Taborda

  2. Laboratory of Medical Mycology IMTSP/LIM53/HCFMUSP, University of São Paulo, São Paulo, Brazil

    Carlos P. Taborda

  3. Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, Rua Botucatu 862, 8th floor, São Paulo, 04021-001, Brazil

    Luiz R. Travassos

Authors
  1. Carlos P. Taborda
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  2. Luiz R. Travassos
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Corresponding author

Correspondence to Luiz R. Travassos .

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Editors and Affiliations

  1. Department of Molecular Immunology, Beckman Research Institute of City of Hope, Duarte, California, USA

    Markus Kalkum

  2. Department of Molecular Immunology, Beckman Research Institute of City of Hope, Duarte, California, USA

    Margarita Semis

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Taborda, C.P., Travassos, L.R. (2017). Peptide Vaccine Against Paracoccidioidomycosis. In: Kalkum, M., Semis, M. (eds) Vaccines for Invasive Fungal Infections. Methods in Molecular Biology, vol 1625. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7104-6_9

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  • DOI: https://doi.org/10.1007/978-1-4939-7104-6_9

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7103-9

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