Abstract
The conventional treatment for fungal diseases usually shows long periods of therapy and the high frequency of relapses and sequels. New strategies of the treatment are necessary. We have shown that the Mycobacterium leprae HSP65 gene can be successfully used as therapy against murine Paracoccidioidomycosis (PCM). Here, we described the methodology of DNAhsp65 immunotherapy in mice infected with the dimorphic fungus Paracoccidioides brasiliensis, one of PCM agent, evaluating cytokines levels, fungal burden, and lung injury. Our results provide a new prospective on the immunotherapy of mycosis.
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Acknowledgment
This work was supported by a grant from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Apoio à Pesquisa do Distrito Federal (FAPDF), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
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Ribeiro, A.M., Amaral, A.C., Felipe, M.S.S., Bocca, A.L. (2017). DNAhsp65 Vaccine as Therapy against Paracoccidioidomycosis. In: Kalkum, M., Semis, M. (eds) Vaccines for Invasive Fungal Infections. Methods in Molecular Biology, vol 1625. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7104-6_7
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DOI: https://doi.org/10.1007/978-1-4939-7104-6_7
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Publisher Name: Humana Press, New York, NY
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Online ISBN: 978-1-4939-7104-6
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