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MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role

  • Lihua Zhang
  • Daniel Miller
  • Qiuping Yang
  • Bin WuEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1617)

Abstract

Even though it is a pandemic health problem worldwide, the pathogenesis of obesity is poorly understood. Recently, emerging studies verified that microRNAs (miRNAs) are involved in complicated metabolic processes including adipocyte differentiation, fat cell formation (adipogenesis), obesity-related insulin resistance and inflammation. Many regulatory networks have been identified in murine adipose tissue, but those in human adipose tissue are not as well known. In addition, miRNAs have been detected in circulation, and thus may be usable as diagnostic indicators. MiRNAs may play an important part in regulating metabolic functions in adipose tissues and, by extension, obesity and its associated disorders. Consequently, they may be potential candidates for therapeutic targets and biomarkers.

Key words

Obesity Adipogenesis Regulatory networks Insulin resistance Biomarkers miRNAs 

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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  • Lihua Zhang
    • 1
  • Daniel Miller
    • 2
  • Qiuping Yang
    • 1
  • Bin Wu
    • 3
    Email author
  1. 1.Department of GeriatricsFirst Affiliated Hospital of Kunming Medical UniversityKunmingChina
  2. 2.School of ComputingUniversity of South AlabamaMobileUSA
  3. 3.Department of EndocrinologyFirst Affiliated Hospital, Kunming Medical UniversityKunmingChina

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