Genomic Regulation of MicroRNA Expression in Disease Development
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MiroRNAs (miRNAs) are an abundant class of regulators of gene expression. Through base paring with messenger RNAs, miRNAs repress the expression levels of other genes, including those encoding transcription factors. On the other hand, the spatial and temporal patterns of miRNAs transcription are subject to regulation by transcription factors. The inter-regulation between miRNAs and TFs integrates two gene regulatory networks—at transcriptional level and post-transcriptional level to fine-tune the gene expression pattern in the development of multicellular organisms. Aberrant regulation at either of these two levels of gene regulation can lead to developmental disorder and disease.
Key wordsMicroRNA Transcription factor Promoter Gene regulatory network