Advertisement

Blood Pressure Monitoring Using Radio Telemetry Method in Mice

  • Yu Wang
  • Sean E. Thatcher
  • Lisa A. CassisEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1614)

Abstract

The TA11PA-C10 implantable transmitter (Data Sciences International, DSI) is designed to measure blood pressure (BP) and activity in freely moving laboratory mice. The fluid filled catheter is placed in the free flowing blood of the systemic artery (inserted into the left carotid artery and extended into the aorta), and the transmitter body is placed in a benign location for long-term biocompatibility. The transmitter can be used to monitor BP in mice (as small as 17 g) under normal physiological and unrestricted conditions 24 h a day while remaining free from stress associated with human interaction. Thus, telemetry is considered the gold standard for BP monitoring in small animals such as mice. However, this methodology does require a good understanding of the system as well as appropriate training to perform the delicate transmitter implantation surgery.

Key words

Blood pressure Radio telemetry Catheter Transmitter Left carotid artery 

References

  1. 1.
    Brockway BP, Mills P, Kramer K (1998) Fully implanted radio-telemetry for monitoring laboratory animals. Lab Anim 27:40–45Google Scholar
  2. 2.
    Mattson DL (1998) Long-term measurement of arterial blood pressure in conscious mice. Am J Physiol 274(2 Pt 2):R564–R570PubMedGoogle Scholar
  3. 3.
    Van Vliet BN, Chafe LL, Antie V et al (2000) Direct and indirect methods used to study arterial blood pressure. J Pharmacol Toxicol Methods 44(2):361–373CrossRefPubMedGoogle Scholar
  4. 4.
    Huetteman DA, Boqie H (2009) Direct blood pressure monitoring in laboratory rodents via implantable radio telemetry. Methods Mol Biol 573:57–73CrossRefPubMedGoogle Scholar
  5. 5.
    Whitesall SE, Hoff JB, Vollmer AP et al (2004) Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods. Am J Physiol Heart Circ Physiol 286(6):H2408–H2415. Epub 2004 February 12CrossRefPubMedGoogle Scholar
  6. 6.
    Xie Z, Su W et al (2015 Jan) Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation. J Clin Invest 125(1):324–336CrossRefPubMedGoogle Scholar
  7. 7.
    Gupte M et al (2012) Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice. Arterioscler Thromb Vasc Biol 32(6):1392–1399CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Department of Pharmacology and Nutritional SciencesUniversity of KentuckyLexingtonUSA
  2. 2.Department of Pharmacology and Nutritional SciencesUniversity of KentuckyLexingtonUSA

Personalised recommendations