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Biofluid Proteomics and Biomarkers in Traumatic Brain Injury

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Neuroproteomics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1598))

Abstract

Traumatic brain injury (TBI) is an injury to the brain caused by an external mechanical force, affecting millions of people worldwide. The disease course and prognosis are often unpredictable, and it can be challenging to determine an early diagnosis in case of mild injury as well as to accurately phenotype the injury. There is currently no cure for TBI—drugs having failed repeatedly in clinical trials—but an intense effort has been put to identify effective neuroprotective treatment. The detection of novel biomarkers, to understand more of the disease mechanism, facilitates early diagnosis, predicts disease progression, and develops molecularly targeted therapies that would be of high clinical interest. Over the last decade, there has been an increasing effort and initiative toward finding TBI-specific biomarker candidates. One promising strategy has been to use state-of-the-art neuroproteomics approaches to assess clinical biofluids and compare the cerebrospinal fluid (CSF) and blood proteome between TBI and control patients or between different subgroups of TBI. In this chapter, we summarize and discuss the status of biofluid proteomics in TBI, with a particular focus on the latest findings.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon

    Safa Azar, Richard Younes, Farah Najdi, Lama Baki, Hussein Ghazale & Kazem Zibara

  2. Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar

    Anwarul Hasan

  3. Biomedical Engineering and Department of Mechanical Engineering, American University of Beirut, Beirut, 1107 2020, Lebanon

    Anwarul Hasan

  4. Center for Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA

    Anwarul Hasan

  5. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

    Anwarul Hasan

  6. Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

    Firas H. Kobeissy

  7. Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, University of Florida, Gainesville, FL, USA

    Firas H. Kobeissy

  8. Department of Biomedical, Odontoiatric and Morphological and Functional Imaging Sciences, University of Messina, A.O.U. “Policlinico G. Martino”, Via Consolare Valeria, Messina, 98125, Italy

    Stefania Mondello M.D., M.P.H., Ph.D.

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  1. Safa Azar
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  2. Anwarul Hasan
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  3. Richard Younes
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  4. Farah Najdi
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  5. Lama Baki
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  6. Hussein Ghazale
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  7. Firas H. Kobeissy
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  8. Kazem Zibara
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  9. Stefania Mondello M.D., M.P.H., Ph.D.
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Correspondence to Stefania Mondello M.D., M.P.H., Ph.D. .

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Editors and Affiliations

  1. Department of Psychiatry, University of Florida McKnight Brain Institute, Gainesville, Florida, USA

    Firas H. Kobeissy

  2. Department of Cell Biology, Microbiology, & Molecular Biology, University of South Florida, Tampa, Florida, USA

    Stanley M. Stevens, Jr.

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Azar, S. et al. (2017). Biofluid Proteomics and Biomarkers in Traumatic Brain Injury. In: Kobeissy, F., Stevens, Jr., S. (eds) Neuroproteomics. Methods in Molecular Biology, vol 1598. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6952-4_3

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  • DOI: https://doi.org/10.1007/978-1-4939-6952-4_3

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