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Lysosomes pp 293–308Cite as

Lysosomal Biology in Cancer

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1594))

Abstract

Cells depend on the lysosome for sequestration and degradation of macromolecules in order to maintain metabolic homeostasis. These membrane-enclosed organelles can receive intracellular and extracellular cargo through endocytosis, phagocytosis, and autophagy. Lysosomes establish acidic environments to activate enzymes that are able to break down biomolecules engulfed through these various pathways. Recent advances in methods to study the lysosome have allowed the discovery of extended roles for the lysosome in various diseases, including cancer, making it an attractive and targetable node for therapeutic intervention. This review focuses on key aspects of lysosomal biology in the context of cancer and how these properties can be exploited for the development of new therapeutic strategies. This will provide a contextual framework for how advances in methodology could be applied in future translational research.

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Authors and Affiliations

  1. Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 777 South Tower PCAM, 34th St. and Civic Center Blvd., Philadelphia, PA, 19104, USA

    Colin Fennelly & Ravi K. Amaravadi

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  1. Colin Fennelly
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  2. Ravi K. Amaravadi
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Correspondence to Ravi K. Amaravadi .

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Editors and Affiliations

  1. Experimental Pathology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

    Karin Öllinger

  2. Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden

    Hanna Appelqvist

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Fennelly, C., Amaravadi, R.K. (2017). Lysosomal Biology in Cancer. In: Öllinger, K., Appelqvist, H. (eds) Lysosomes. Methods in Molecular Biology, vol 1594. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6934-0_19

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  • DOI: https://doi.org/10.1007/978-1-4939-6934-0_19

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