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Metals in the Brain pp 243–257Cite as

Measuring Changes in Brain Manganese or Iron Using Magnetic Resonance Imaging (MRI)

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Part of the book series: Neuromethods ((NM,volume 124))

Abstract

There are many diseases of the brain in which the transition metals manganese (Mn) and iron (Fe) are known or suspected to play a role. The magnetic resonance imaging (MRI) signal is sensitive to these paramagnetic metals; hence, quantitative MRI (qMRI) can be used to measure changes in Mn or Fe concentrations in vivo in animal models of brain disease. Here, we specifically describe how to measure changes in Mn in the brain from qMRI measurements of the longitudinal relaxation rate, R 1, in rats at a magnetic field strength of 7 T. We further discuss how to extend the method to measure changes in Mn or Fe from other qMRI parameters.

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Author information

Authors and Affiliations

  1. Imaging Research, Sunnybrook Research Institute, Toronto, ON, Canada

    Kimberly L. Desmond

  2. Department of Psychology, Neuroscience and Behavior, McMaster University, 1280 Main Street West, Hamilton, ON, Canada, L8S 4K1

    Nicholas A. Bock

Authors
  1. Kimberly L. Desmond
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  2. Nicholas A. Bock
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Corresponding author

Correspondence to Nicholas A. Bock .

Editor information

Editors and Affiliations

  1. Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia

    Anthony R. White

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Desmond, K.L., Bock, N.A. (2017). Measuring Changes in Brain Manganese or Iron Using Magnetic Resonance Imaging (MRI). In: White, A. (eds) Metals in the Brain. Neuromethods, vol 124. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6918-0_13

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  • DOI: https://doi.org/10.1007/978-1-4939-6918-0_13

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6916-6

  • Online ISBN: 978-1-4939-6918-0

  • eBook Packages: Springer Protocols

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